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Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute.

Truedsson, Anna; Wang, Jian-Sheng LU ; Lindberg, Pia and Warfvinge, Gunnar (2016) In Journal of Functional Biomaterials 7(1).
Abstract
The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. Torsional resistance was measured after 1 day, and after 6 and 12 weeks. Implant areas without bone substitute were analyzed histologically for comparison. The torsional resistance increased over time as the screws were osseointegrated. There was no difference in resistance between screws embedded in the bone substitute and control screws. The bone... (More)
The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. Torsional resistance was measured after 1 day, and after 6 and 12 weeks. Implant areas without bone substitute were analyzed histologically for comparison. The torsional resistance increased over time as the screws were osseointegrated. There was no difference in resistance between screws embedded in the bone substitute and control screws. The bone apposition was more pronounced on the proximal side of the screw than on the distal side. Cerament™ is capable of conducting bone growth from a cortical bone surface. The newly formed bone in this application does not significantly add to the osseointegrative strength of the implant screw, as measured by torque resistance, during the first 12 weeks. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Functional Biomaterials
volume
7
issue
1
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • pmid:26751485
ISSN
2079-4983
DOI
10.3390/jfb7010002
language
English
LU publication?
yes
id
7db54c27-fc73-4ce3-9bbf-da2553fe3d26 (old id 8592446)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26751485?dopt=Abstract
date added to LUP
2016-02-02 21:24:34
date last changed
2016-09-20 03:19:33
@article{7db54c27-fc73-4ce3-9bbf-da2553fe3d26,
  abstract     = {The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. Torsional resistance was measured after 1 day, and after 6 and 12 weeks. Implant areas without bone substitute were analyzed histologically for comparison. The torsional resistance increased over time as the screws were osseointegrated. There was no difference in resistance between screws embedded in the bone substitute and control screws. The bone apposition was more pronounced on the proximal side of the screw than on the distal side. Cerament™ is capable of conducting bone growth from a cortical bone surface. The newly formed bone in this application does not significantly add to the osseointegrative strength of the implant screw, as measured by torque resistance, during the first 12 weeks.},
  author       = {Truedsson, Anna and Wang, Jian-Sheng and Lindberg, Pia and Warfvinge, Gunnar},
  issn         = {2079-4983},
  language     = {eng},
  number       = {1},
  publisher    = {Multidisciplinary Digital Publishing Institute (MDPI)},
  series       = {Journal of Functional Biomaterials},
  title        = {Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute.},
  url          = {http://dx.doi.org/10.3390/jfb7010002},
  volume       = {7},
  year         = {2016},
}