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Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.

Mattsson, Niklas LU ; Schott, Jonathan M; Hardy, John; Turner, Martin R and Zetterberg, Henrik (2016) In Journal of Neurology, Neurosurgery, and Psychiatry 87. p.1000-1004
Abstract
Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks... (More)
Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks and neuronal populations, we focus here on what is known about selective vulnerability-related factors that might explain the differential phenotypic expressions of the same disease-in this case, typical and atypical forms of Alzheimer's disease. Whereas considerable progress has been made in this area, much is yet to be elucidated; further studies comparing different phenotypic variants aimed at identifying both vulnerability and resilience factors may provide valuable insights into disease pathogenesis, and suggest novel targets for therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neurology, Neurosurgery, and Psychiatry
volume
87
pages
1000 - 1004
publisher
BMJ Publishing Group
external identifiers
  • PMID:26746185
  • Scopus:84979791955
ISSN
1468-330X
DOI
10.1136/jnnp-2015-311321
language
English
LU publication?
yes
id
04528990-ab4c-4a59-9e3c-81f60798972c (old id 8592617)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26746185?dopt=Abstract
date added to LUP
2016-02-02 09:40:27
date last changed
2017-02-02 09:47:39
@article{04528990-ab4c-4a59-9e3c-81f60798972c,
  abstract     = {Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurodegenerative diseases. Yet the increasing complexity of molecular histopathology at the cellular level in neurodegenerative disorders frequently appears at odds with phenotyping based on clinically-directed, macroscopic regional brain involvement. While cross-disease comparisons can provide insights into the differential vulnerability of networks and neuronal populations, we focus here on what is known about selective vulnerability-related factors that might explain the differential phenotypic expressions of the same disease-in this case, typical and atypical forms of Alzheimer's disease. Whereas considerable progress has been made in this area, much is yet to be elucidated; further studies comparing different phenotypic variants aimed at identifying both vulnerability and resilience factors may provide valuable insights into disease pathogenesis, and suggest novel targets for therapy.},
  author       = {Mattsson, Niklas and Schott, Jonathan M and Hardy, John and Turner, Martin R and Zetterberg, Henrik},
  issn         = {1468-330X},
  language     = {eng},
  month        = {01},
  pages        = {1000--1004},
  publisher    = {BMJ Publishing Group},
  series       = {Journal of Neurology, Neurosurgery, and Psychiatry},
  title        = {Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1136/jnnp-2015-311321},
  volume       = {87},
  year         = {2016},
}