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In Vivo Reprogramming for Brain and Spinal Cord Repair(1,2,3).

Chen, Gong; Wernig, Marius; Berninger, Benedikt; Nakafuku, Masato; Parmar, Malin LU and Zhang, Chun-Li (2015) In eNeuro 2(5).
Abstract
Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review... (More)
Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
eNeuro
volume
2
issue
5
publisher
Society for Neuroscience
external identifiers
  • pmid:26730402
  • scopus:85019249355
ISSN
2373-2822
DOI
10.1523/ENEURO.0106-15.2015
language
English
LU publication?
yes
id
c917820b-886b-4338-9218-e6da7a2f19df (old id 8593175)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26730402?dopt=Abstract
date added to LUP
2016-02-10 10:43:51
date last changed
2017-11-05 04:06:46
@article{c917820b-886b-4338-9218-e6da7a2f19df,
  abstract     = {Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC.},
  author       = {Chen, Gong and Wernig, Marius and Berninger, Benedikt and Nakafuku, Masato and Parmar, Malin and Zhang, Chun-Li},
  issn         = {2373-2822},
  language     = {eng},
  number       = {5},
  publisher    = {Society for Neuroscience},
  series       = {eNeuro},
  title        = {In Vivo Reprogramming for Brain and Spinal Cord Repair(1,2,3).},
  url          = {http://dx.doi.org/10.1523/ENEURO.0106-15.2015},
  volume       = {2},
  year         = {2015},
}