Defining the hematopoietic stem cell niche: the chicken and the egg conundrum
(2011) In Journal of Cellular Biochemistry 112(6). p.90-1486- Abstract
- Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the... (More)
- Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain? (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8594820
- author
- Singbrant, Sofie LU ; Askmyr, M. ; Purton, L. E. and Walkley, C. R.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Bone Marrow Cells/cytology, Hematopoietic Stem Cells/*cytology, Humans, Mice, Stem Cell Niche/*cytology
- in
- Journal of Cellular Biochemistry
- volume
- 112
- issue
- 6
- pages
- 90 - 1486
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:79954480252
- pmid:21503954
- ISSN
- 0730-2312
- DOI
- 10.1002/jcb.23085
- language
- English
- LU publication?
- no
- additional info
- 6
- id
- 3c293411-f860-4421-af24-3963168e7da4 (old id 8594820)
- date added to LUP
- 2016-04-01 10:39:18
- date last changed
- 2022-01-26 01:13:22
@article{3c293411-f860-4421-af24-3963168e7da4, abstract = {{Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?}}, author = {{Singbrant, Sofie and Askmyr, M. and Purton, L. E. and Walkley, C. R.}}, issn = {{0730-2312}}, keywords = {{Animals; Bone Marrow Cells/cytology; Hematopoietic Stem Cells/*cytology; Humans; Mice; Stem Cell Niche/*cytology}}, language = {{eng}}, number = {{6}}, pages = {{90--1486}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Cellular Biochemistry}}, title = {{Defining the hematopoietic stem cell niche: the chicken and the egg conundrum}}, url = {{http://dx.doi.org/10.1002/jcb.23085}}, doi = {{10.1002/jcb.23085}}, volume = {{112}}, year = {{2011}}, }