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Defining the hematopoietic stem cell niche: the chicken and the egg conundrum

Singbrant, Sofie LU ; Askmyr, M.; Purton, L. E. and Walkley, C. R. (2011) In Journal of Cellular Biochemistry 112(6). p.90-1486
Abstract
Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the... (More)
Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain? (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Bone Marrow Cells/cytology, Hematopoietic Stem Cells/*cytology, Humans, Mice, Stem Cell Niche/*cytology
in
Journal of Cellular Biochemistry
volume
112
issue
6
pages
90 - 1486
publisher
Wiley-Blackwell
external identifiers
  • scopus:79954480252
ISSN
0730-2312
DOI
10.1002/jcb.23085
language
English
LU publication?
no
id
3c293411-f860-4421-af24-3963168e7da4 (old id 8594820)
date added to LUP
2016-02-02 13:10:49
date last changed
2017-01-01 03:46:56
@article{3c293411-f860-4421-af24-3963168e7da4,
  abstract     = {Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?},
  author       = {Singbrant, Sofie and Askmyr, M. and Purton, L. E. and Walkley, C. R.},
  issn         = {0730-2312},
  keyword      = {Animals,Bone Marrow Cells/cytology,Hematopoietic Stem Cells/*cytology,Humans,Mice,Stem Cell Niche/*cytology},
  language     = {eng},
  number       = {6},
  pages        = {90--1486},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Cellular Biochemistry},
  title        = {Defining the hematopoietic stem cell niche: the chicken and the egg conundrum},
  url          = {http://dx.doi.org/10.1002/jcb.23085},
  volume       = {112},
  year         = {2011},
}