Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.
Höglund, Mattias LU ; Gisselsson Nord, David LU ; Hansen, Gunnar B ; Säll, Torbjörn LU and Mitelman, Felix LU
(2002)
In Cancer Research
62(9).
p.2675-2680
- Abstract
- More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The... (More)
- More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The distribution of the number of imbalances/tumor showed a monomodal appearance, indicating that one single mode of karyotypic evolution is operating in this tumor type. We show that there exists a temporal order with respect to the appearance of chromosomal imbalances. The imbalances +1pq, 1q-, 3p-, and +7 appear earlier than expected from random events, and two cytogenetic pathways, one initiated by +1q and followed by 11q- and -22, the other initiated by either 3p- or 1q- and followed by 1p-, 3q-, and 6q-, can be discerned. We also show that +7 and +8q behave independently of the other imbalances and cannot, by simple means, be incorporated in the identified pathway scheme. Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/107909
- author
- Höglund, Mattias
LU
; Gisselsson Nord, David
LU
; Hansen, Gunnar B
; Säll, Torbjörn
LU
and Mitelman, Felix
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breast Neoplasms : genetics, Adenocarcinoma : genetics, Chromosome Aberrations, Human, Multivariate Analysis, Karyotyping
- in
- Cancer Research
- volume
- 62
- issue
- 9
- pages
- 2675 - 2680
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- pmid:11980667
- wos:000175265000037
- scopus:0036570224
- ISSN
- 1538-7445
- language
- English
- LU publication?
- yes
- id
- 859b30ef-e916-441f-afad-768fefc77ee6 (old id 107909)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11980667&dopt=Abstract
- http://cancerres.aacrjournals.org/cgi/content/full/62/9/2675
- date added to LUP
- 2016-04-01 15:31:45
- date last changed
- 2022-05-15 23:34:53
@article{859b30ef-e916-441f-afad-768fefc77ee6,
abstract = {{More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The distribution of the number of imbalances/tumor showed a monomodal appearance, indicating that one single mode of karyotypic evolution is operating in this tumor type. We show that there exists a temporal order with respect to the appearance of chromosomal imbalances. The imbalances +1pq, 1q-, 3p-, and +7 appear earlier than expected from random events, and two cytogenetic pathways, one initiated by +1q and followed by 11q- and -22, the other initiated by either 3p- or 1q- and followed by 1p-, 3q-, and 6q-, can be discerned. We also show that +7 and +8q behave independently of the other imbalances and cannot, by simple means, be incorporated in the identified pathway scheme. Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances.}},
author = {{Höglund, Mattias and Gisselsson Nord, David and Hansen, Gunnar B and Säll, Torbjörn and Mitelman, Felix}},
issn = {{1538-7445}},
keywords = {{Breast Neoplasms : genetics; Adenocarcinoma : genetics; Chromosome Aberrations; Human; Multivariate Analysis; Karyotyping}},
language = {{eng}},
number = {{9}},
pages = {{2675--2680}},
publisher = {{American Association for Cancer Research Inc.}},
series = {{Cancer Research}},
title = {{Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11980667&dopt=Abstract}},
volume = {{62}},
year = {{2002}},
}