Advanced

Timing of onset affects arthritis presentation pattern in antisynthetase syndrome

Gonzalez-Gay, MA; Cagnotto, G LU ; Cavagna, L and , (2018) In Clinical and Experimental Rheumatology 36(1). p.44-49
Abstract
Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to... (More)
Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility. © Clinical and Experimental Rheumatology 2018. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antisynthetase syndrome, Arthritis pattern, Timing of onset, azathioprine, cyclophosphamide, cyclosporine, enzyme antibody, hydroxychloroquine, immunoglobulin M, mycophenolate mofetil, prednisone, rheumatoid factor, synthetase antibody, unclassified drug, autoantibody, biological marker, adult, antibody detection, antisynthetase syndrome, arthritis, Article, bone radiography, cohort analysis, controlled study, disease association, disease classification, disease course, female, fever, follow up, foot disease, hand disease, human, major clinical study, male, polyarthritis, practice guideline, priority journal, Raynaud phenomenon, retrospective study, blood, clinical trial, comparative study, Europe, immunology, Mexico, middle aged, multicenter study, myositis, phenotype, prevalence, prognosis, risk factor, time factor, Adult, Arthritis, Autoantibodies, Biomarkers, Female, Humans, Male, Middle Aged, Myositis, Phenotype, Prevalence, Prognosis, Retrospective Studies, Risk Factors, Time Factors
in
Clinical and Experimental Rheumatology
volume
36
issue
1
pages
44 - 49
publisher
Pacini
external identifiers
  • scopus:85042159097
ISSN
1593-098X
language
English
LU publication?
yes
id
85ad6161-3883-455e-8849-9265b0786865
alternative location
https://www.clinexprheumatol.org/abstract.asp?a=11506
date added to LUP
2019-07-04 14:17:19
date last changed
2019-10-15 07:10:12
@article{85ad6161-3883-455e-8849-9265b0786865,
  abstract     = {Objective To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). Methods The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Results 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). Conclusion In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility. © Clinical and Experimental Rheumatology 2018.},
  author       = {Gonzalez-Gay, MA and Cagnotto, G and Cavagna, L and , },
  issn         = {1593-098X},
  keyword      = {Antisynthetase syndrome,Arthritis pattern,Timing of onset,azathioprine,cyclophosphamide,cyclosporine,enzyme antibody,hydroxychloroquine,immunoglobulin M,mycophenolate mofetil,prednisone,rheumatoid factor,synthetase antibody,unclassified drug,autoantibody,biological marker,adult,antibody detection,antisynthetase syndrome,arthritis,Article,bone radiography,cohort analysis,controlled study,disease association,disease classification,disease course,female,fever,follow up,foot disease,hand disease,human,major clinical study,male,polyarthritis,practice guideline,priority journal,Raynaud phenomenon,retrospective study,blood,clinical trial,comparative study,Europe,immunology,Mexico,middle aged,multicenter study,myositis,phenotype,prevalence,prognosis,risk factor,time factor,Adult,Arthritis,Autoantibodies,Biomarkers,Female,Humans,Male,Middle Aged,Myositis,Phenotype,Prevalence,Prognosis,Retrospective Studies,Risk Factors,Time Factors},
  language     = {eng},
  number       = {1},
  pages        = {44--49},
  publisher    = {Pacini},
  series       = {Clinical and Experimental Rheumatology},
  title        = {Timing of onset affects arthritis presentation pattern in antisynthetase syndrome},
  volume       = {36},
  year         = {2018},
}