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Real-life clinical outcomes with everolimus eluting platinum chromium stent with an abluminal biodegradable polymer in patients from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)

Sarno, Giovanna; Lagerqvist, Bo; Olivecrona, Göran LU ; Varenhorst, Christoph; Danielewicz, Mikael; Hambraeus, Kristina; Lindholm, Daniel; Råmunddal, Truls; Witt, Nils and James, Stefan (2017) In Catheterization and Cardiovascular Interventions 90(6). p.881-887
Abstract

Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new generation drug eluting stents (n-DES) with >1,000 implantations in Sweden between March 2013 and October 2015. Restenosis, definite stent thrombosis (ST), myocardial infarction (MI) and death rates were assessed using propensity score and Cox regression analyses. Results: A total of 7,886 of Synergy stents and 64,429 other n-DES (BioMatrix, N =... (More)

Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new generation drug eluting stents (n-DES) with >1,000 implantations in Sweden between March 2013 and October 2015. Restenosis, definite stent thrombosis (ST), myocardial infarction (MI) and death rates were assessed using propensity score and Cox regression analyses. Results: A total of 7,886 of Synergy stents and 64,429 other n-DES (BioMatrix, N = 1,953; Orsiro, N = 4,946; Promus Element Plus, N= 2,543; Promus Premier, N= 20,414; Xience Xpedition, N= 7,971, Resolute/Resolute Integrity, N = 19,021; Ultimaster, N = 1,156; Resolute Onyx, N = 6,425) were implanted in 42,357 procedures. Restenosis and stent thrombosis occurred in 642 and 314 cases, respectively, in the overall population at 1 year. The cumulative rate of restenosis (1.1% vs. 1.0%, adjusted HR: 1.24 95% CI: 0.88–1.75; P = 0.21) and ST (0.4% vs. 0.5%, adjusted HR: 0.97; 95% CI: 0.63–1.50; P = 0.17) up to 1 year was low in both the Synergy group and the other n-DES group. Death occurred in 5.2% versus 4.5% (adjusted HR: 1.14; 95% CI: 0.96–1.36; P = 0.11) and MI in 3.2% versus 3.5%, (adjusted HR: 1.11; 95% CI: 0.93–1.33; P = 0.24) up to 1 year. Conclusions: In a large real-life population the Synergy stent appears to be safe and effective with a low rate of restenosis and ST comparable with other n-DES.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
drug eluting, percutaneous coronary intervention, restenosis, stent, stent thrombosis
in
Catheterization and Cardiovascular Interventions
volume
90
issue
6
pages
7 pages
external identifiers
  • scopus:85027372320
ISSN
1522-1946
DOI
10.1002/ccd.27030
language
English
LU publication?
no
id
85bb3f19-a4e5-46f7-abc7-9f725c6b48d6
date added to LUP
2018-01-25 07:20:45
date last changed
2018-11-04 04:35:05
@article{85bb3f19-a4e5-46f7-abc7-9f725c6b48d6,
  abstract     = {<p>Background: No previous studies have evaluated the performance of the Synergy stent in a large real-life population. Objectives: To describe the initial real-life experience with a novel everolimus eluting platinum chromium stent with abluminal biodegradable polymer (SYNERGY) in unselected patients from a nationwide registry. Methods: All implanted Synergy stents were compared with other new generation drug eluting stents (n-DES) with &gt;1,000 implantations in Sweden between March 2013 and October 2015. Restenosis, definite stent thrombosis (ST), myocardial infarction (MI) and death rates were assessed using propensity score and Cox regression analyses. Results: A total of 7,886 of Synergy stents and 64,429 other n-DES (BioMatrix, N = 1,953; Orsiro, N = 4,946; Promus Element Plus, N= 2,543; Promus Premier, N= 20,414; Xience Xpedition, N= 7,971, Resolute/Resolute Integrity, N = 19,021; Ultimaster, N = 1,156; Resolute Onyx, N = 6,425) were implanted in 42,357 procedures. Restenosis and stent thrombosis occurred in 642 and 314 cases, respectively, in the overall population at 1 year. The cumulative rate of restenosis (1.1% vs. 1.0%, adjusted HR: 1.24 95% CI: 0.88–1.75; P = 0.21) and ST (0.4% vs. 0.5%, adjusted HR: 0.97; 95% CI: 0.63–1.50; P = 0.17) up to 1 year was low in both the Synergy group and the other n-DES group. Death occurred in 5.2% versus 4.5% (adjusted HR: 1.14; 95% CI: 0.96–1.36; P = 0.11) and MI in 3.2% versus 3.5%, (adjusted HR: 1.11; 95% CI: 0.93–1.33; P = 0.24) up to 1 year. Conclusions: In a large real-life population the Synergy stent appears to be safe and effective with a low rate of restenosis and ST comparable with other n-DES.</p>},
  author       = {Sarno, Giovanna and Lagerqvist, Bo and Olivecrona, Göran and Varenhorst, Christoph and Danielewicz, Mikael and Hambraeus, Kristina and Lindholm, Daniel and Råmunddal, Truls and Witt, Nils and James, Stefan},
  issn         = {1522-1946},
  keyword      = {drug eluting,percutaneous coronary intervention,restenosis,stent,stent thrombosis},
  language     = {eng},
  month        = {11},
  number       = {6},
  pages        = {881--887},
  series       = {Catheterization and Cardiovascular Interventions},
  title        = {Real-life clinical outcomes with everolimus eluting platinum chromium stent with an abluminal biodegradable polymer in patients from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)},
  url          = {http://dx.doi.org/10.1002/ccd.27030},
  volume       = {90},
  year         = {2017},
}