Syndecan receptors : pericellular regulators in development and inflammatory disease
Gopal, Sandeep LU
; Arokiasamy, Samantha
; Pataki, Csilla
; Whiteford, James R
and Couchman, John R
(2021)
In Open biology
11(2).
p.1-19
- Abstract
- The syndecans are the major family of transmembrane proteoglycans,
usually bearing multiple heparan sulfate chains. They are present on
virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both
vertebrates and invertebrates have shown that syndecans link to the actin
cytoskeleton and can fine-tune cell adhesion, migration, junction formation,
polarity and differentiation. Although often associated as co-receptors with
other classes of receptors (e.g. integrins, growth factor and morphogen
receptors), syndecans can nonetheless signal to the cytoplasm in discrete
ways. Syndecan expression levels are upregulated in... (More) - The syndecans are the major family of transmembrane proteoglycans,
usually bearing multiple heparan sulfate chains. They are present on
virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both
vertebrates and invertebrates have shown that syndecans link to the actin
cytoskeleton and can fine-tune cell adhesion, migration, junction formation,
polarity and differentiation. Although often associated as co-receptors with
other classes of receptors (e.g. integrins, growth factor and morphogen
receptors), syndecans can nonetheless signal to the cytoplasm in discrete
ways. Syndecan expression levels are upregulated in development, tissue
repair and an array of human diseases, which has led to the increased
appreciation that they may be important in pathogenesis not only as
diagnostic or prognostic agents, but also as potential targets. Here, their
functions in development and inflammatory diseases are summarized,
including their potential roles as conduits for viral pathogen entry into cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/85bed797-5dea-4d9b-9f0c-aaa20ccf17b7
- author
- Gopal, Sandeep
LU
; Arokiasamy, Samantha
; Pataki, Csilla
; Whiteford, James R
and Couchman, John R
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- in
- Open biology
- volume
- 11
- issue
- 2
- article number
- 200377
- pages
- 1 - 19
- publisher
- Royal Society Publishing
- external identifiers
-
- scopus:85101454674
- pmid:33561383
- ISSN
- 2046-2441
- DOI
- 10.1098/rsob.200377
- language
- English
- LU publication?
- no
- id
- 85bed797-5dea-4d9b-9f0c-aaa20ccf17b7
- date added to LUP
- 2021-10-25 12:53:51
- date last changed
- 2024-06-16 21:33:11
@article{85bed797-5dea-4d9b-9f0c-aaa20ccf17b7,
abstract = {{The syndecans are the major family of transmembrane proteoglycans,<br/>usually bearing multiple heparan sulfate chains. They are present on<br/>virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both<br/>vertebrates and invertebrates have shown that syndecans link to the actin<br/>cytoskeleton and can fine-tune cell adhesion, migration, junction formation,<br/>polarity and differentiation. Although often associated as co-receptors with<br/>other classes of receptors (e.g. integrins, growth factor and morphogen<br/>receptors), syndecans can nonetheless signal to the cytoplasm in discrete<br/>ways. Syndecan expression levels are upregulated in development, tissue<br/>repair and an array of human diseases, which has led to the increased<br/>appreciation that they may be important in pathogenesis not only as<br/>diagnostic or prognostic agents, but also as potential targets. Here, their<br/>functions in development and inflammatory diseases are summarized,<br/>including their potential roles as conduits for viral pathogen entry into cells.}},
author = {{Gopal, Sandeep and Arokiasamy, Samantha and Pataki, Csilla and Whiteford, James R and Couchman, John R}},
issn = {{2046-2441}},
language = {{eng}},
number = {{2}},
pages = {{1--19}},
publisher = {{Royal Society Publishing}},
series = {{Open biology}},
title = {{Syndecan receptors : pericellular regulators in development and inflammatory disease}},
url = {{http://dx.doi.org/10.1098/rsob.200377}},
doi = {{10.1098/rsob.200377}},
volume = {{11}},
year = {{2021}},
}