Neuromuscular adaptations in older males and females with knee osteoarthritis during weight-bearing force control
(2018) In Knee 25(1). p.40-50- Abstract
Background: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. Objective: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading. Methods: Thirty adults with OA and 36 controls completed a standing ground reaction force (GRF) matching protocol requiring participants to expose equal body weight to each leg and modulate horizontal GRFs while... (More)
Background: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. Objective: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading. Methods: Thirty adults with OA and 36 controls completed a standing ground reaction force (GRF) matching protocol requiring participants to expose equal body weight to each leg and modulate horizontal GRFs while maintaining constant joint positions. Electromyography was plotted as a function of GRF direction to depict muscle activation patterns. Muscles were classified as a general joint stabilizer, specific joint stabilizer or moment actuator by quantifying activation patterns with a test of asymmetry, specificity index and mean direction of activity. Lower limb kinematics and kinetics were also recorded. Results: In general, muscle roles as it relates to joint stability did not differ between groups. Compared to controls, both males and females with OA demonstrated greater rectus femoris activity and reduced knee rotation moments. Females with OA had significantly greater biceps femoris and gastrocnemius activity during respective lateral, and anterior–medial loading directions compared to males with OA. Conclusions: We identified fundamental differences in muscular stabilization strategies in older adults with OA as well as sex-related changes in neuromuscular function that may influence joint loading conditions and provide insight into the greater incidence of knee OA in females.
(Less)
- author
- Bigham, Heather J. ; Flaxman, Teresa E. ; Smith, Andrew J.J. and Benoit, Daniel L. LU
- publishing date
- 2018-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Electromyography, Knee stability, Neuromuscular control, Older adults, Osteoarthritis, Sex differences
- in
- Knee
- volume
- 25
- issue
- 1
- pages
- 40 - 50
- publisher
- Elsevier
- external identifiers
-
- pmid:29174844
- scopus:85034751430
- ISSN
- 0968-0160
- DOI
- 10.1016/j.knee.2017.06.004
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2017 Elsevier B.V.
- id
- 85d8ea3f-f298-4d7a-b92b-46cdd185ac33
- date added to LUP
- 2023-08-24 16:29:32
- date last changed
- 2024-10-05 18:44:30
@article{85d8ea3f-f298-4d7a-b92b-46cdd185ac33,
abstract = {{<p>Background: Females exhibit significantly greater incidence, prevalence, and severity of osteoarthritis (OA) compared to males. Despite known biological, morphological, and functional differences between males and females, there has been little sex-related investigation into sex-specific biomechanical and neuromuscular responses to OA. Objective: To identify sex-related differences in OA-affected adults and within-sex differences between healthy and OA-affected adults' muscular activation patterns during lower limb loading. Methods: Thirty adults with OA and 36 controls completed a standing ground reaction force (GRF) matching protocol requiring participants to expose equal body weight to each leg and modulate horizontal GRFs while maintaining constant joint positions. Electromyography was plotted as a function of GRF direction to depict muscle activation patterns. Muscles were classified as a general joint stabilizer, specific joint stabilizer or moment actuator by quantifying activation patterns with a test of asymmetry, specificity index and mean direction of activity. Lower limb kinematics and kinetics were also recorded. Results: In general, muscle roles as it relates to joint stability did not differ between groups. Compared to controls, both males and females with OA demonstrated greater rectus femoris activity and reduced knee rotation moments. Females with OA had significantly greater biceps femoris and gastrocnemius activity during respective lateral, and anterior–medial loading directions compared to males with OA. Conclusions: We identified fundamental differences in muscular stabilization strategies in older adults with OA as well as sex-related changes in neuromuscular function that may influence joint loading conditions and provide insight into the greater incidence of knee OA in females.</p>}},
author = {{Bigham, Heather J. and Flaxman, Teresa E. and Smith, Andrew J.J. and Benoit, Daniel L.}},
issn = {{0968-0160}},
keywords = {{Electromyography; Knee stability; Neuromuscular control; Older adults; Osteoarthritis; Sex differences}},
language = {{eng}},
number = {{1}},
pages = {{40--50}},
publisher = {{Elsevier}},
series = {{Knee}},
title = {{Neuromuscular adaptations in older males and females with knee osteoarthritis during weight-bearing force control}},
url = {{http://dx.doi.org/10.1016/j.knee.2017.06.004}},
doi = {{10.1016/j.knee.2017.06.004}},
volume = {{25}},
year = {{2018}},
}