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Amelioration of ischaemic brain damage by postischaemic treatment with flunarizine

Deshpande, J. K. and Wieloch, T. LU (1985) In Neurological Research 7(1). p.27-29
Abstract
The effect of flunarizine, a calcium entry blocker, on ischaemic damage was investigated using a new model of forebrain ischaemia. Fasted rats were subjected to nine minutes ischaemia and one week recovery. One group served as control; a second was pretreated orally with flunarizine; a third group received postischaemic flunarizine treatment Focussing on the hippocampus, an area of high susceptibility to ischaemic damage, we report that flunarizine treatment significantly reduced neuronal necrosis. Importantly, the amelioration of necrosis was also observed when flunarizine was administered 5 min following resumption of cerebral perfusion.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurological Research
volume
7
issue
1
pages
3 pages
publisher
Butterworth-Heinemann
external identifiers
  • scopus:0021998311
ISSN
0161-6412
DOI
10.1080/01616412.1985.11739696
language
English
LU publication?
yes
id
85e717e0-1b44-4380-878d-f79c4c3015b0
date added to LUP
2019-06-13 17:18:31
date last changed
2019-08-19 12:52:01
@article{85e717e0-1b44-4380-878d-f79c4c3015b0,
  abstract     = {The effect of flunarizine, a calcium entry blocker, on ischaemic damage was investigated using a new model of forebrain ischaemia. Fasted rats were subjected to nine minutes ischaemia and one week recovery. One group served as control; a second was pretreated orally with flunarizine; a third group received postischaemic flunarizine treatment Focussing on the hippocampus, an area of high susceptibility to ischaemic damage, we report that flunarizine treatment significantly reduced neuronal necrosis. Importantly, the amelioration of necrosis was also observed when flunarizine was administered 5 min following resumption of cerebral perfusion.},
  author       = {Deshpande, J. K. and Wieloch, T.},
  issn         = {0161-6412},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {27--29},
  publisher    = {Butterworth-Heinemann},
  series       = {Neurological Research},
  title        = {Amelioration of ischaemic brain damage by postischaemic treatment with flunarizine},
  url          = {http://dx.doi.org/10.1080/01616412.1985.11739696},
  volume       = {7},
  year         = {1985},
}