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Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort

Carayol, Marion; Leitzmann, Michael F.; Ferrari, Pietro; Zamora-Ros, Raul; Achaintre, David; Stepien, Magdalena; Schmidt, Julie A; Travis, Ruth C; Overvad, Kim and Tjønneland, Anne, et al. (2017) In Journal of Proteome Research 16(9). p.3137-3146
Abstract

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential... (More)

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.

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publication status
published
subject
keywords
blood, body mass index, metabolic profiling, obesity, targeted metabolome
in
Journal of Proteome Research
volume
16
issue
9
pages
10 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85028748844
  • wos:000410003500003
ISSN
1535-3893
DOI
10.1021/acs.jproteome.6b01062
language
English
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yes
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85f578b9-6742-422e-9df9-04faf0a49b8d
date added to LUP
2017-09-26 14:39:23
date last changed
2018-01-16 13:26:52
@article{85f578b9-6742-422e-9df9-04faf0a49b8d,
  abstract     = {<p>Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.</p>},
  author       = {Carayol, Marion and Leitzmann, Michael F. and Ferrari, Pietro and Zamora-Ros, Raul and Achaintre, David and Stepien, Magdalena and Schmidt, Julie A and Travis, Ruth C and Overvad, Kim and Tjønneland, Anne and Hansen, Louise and Kaaks, Rudolf and Kühn, Tilman and Boeing, Heiner and Bachlechner, Ursula and Trichopoulou, Antonia and Bamia, Christina and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Vineis, Paolo and Panico, Salvatore and Quirós, J Ramón and Sánchez-Cantalejo, Emilio and Huerta, José María and Ardanaz, Eva and Arriola, Larraitz and Agudo, Antonio and Nilsson, Jan and Melander, Olle and Bueno de Mesquita, Bas and Peeters, Petra H. and Wareham, Nick and Khaw, Kay-Tee and Jenab, Mazda and Key, Timothy J and Scalbert, Augustin and Rinaldi, Sabina},
  issn         = {1535-3893},
  keyword      = {blood,body mass index,metabolic profiling,obesity,targeted metabolome},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {3137--3146},
  publisher    = {The American Chemical Society},
  series       = {Journal of Proteome Research},
  title        = {Blood Metabolic Signatures of Body Mass Index : A Targeted Metabolomics Study in the EPIC Cohort},
  url          = {http://dx.doi.org/10.1021/acs.jproteome.6b01062},
  volume       = {16},
  year         = {2017},
}