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The Importance of Magnesium in the Human Body: A Systematic Literature review

Glasdam, Sidsel-Marie; Glasdam, Stinne LU and Peters, Günther H. (2016) In Advances in Clinical Chemistry 73. p.169-193
Abstract
Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents... (More)
Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents current analytical challenges in obtaining accurate and reproducible test results for magnesium. © 2016 Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
magmesium, human body, measurement
in
Advances in Clinical Chemistry
editor
Makowski, Gregory S. and
volume
73
pages
169 - 193
publisher
Academic Press
external identifiers
  • scopus:84954271400
  • wos:000377029300007
ISSN
0065-2423
ISBN
978-0-12-804690-6
DOI
10.1016/bs.acc.2015.10.002
language
English
LU publication?
yes
id
5aa23e3e-96b1-4a8c-807b-e2bab6bc6e8f (old id 8625900)
date added to LUP
2016-02-15 14:00:34
date last changed
2017-09-18 11:28:50
@inbook{5aa23e3e-96b1-4a8c-807b-e2bab6bc6e8f,
  abstract     = {Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents current analytical challenges in obtaining accurate and reproducible test results for magnesium. © 2016 Elsevier Inc.},
  author       = {Glasdam, Sidsel-Marie and Glasdam, Stinne and Peters, Günther H.},
  editor       = {Makowski, Gregory S.},
  isbn         = {978-0-12-804690-6 },
  issn         = {0065-2423},
  keyword      = {magmesium,human body,measurement},
  language     = {eng},
  pages        = {169--193},
  publisher    = {Academic Press},
  series       = {Advances in Clinical Chemistry},
  title        = {The Importance of Magnesium in the Human Body: A Systematic Literature review},
  url          = {http://dx.doi.org/10.1016/bs.acc.2015.10.002},
  volume       = {73},
  year         = {2016},
}