Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Levels of immunoreactive insulin, neurotensin, and bombesin in porcine colostrum and milk

Weström, B. R. LU ; Ekman, R. ; Svendsen, L. ; Svendsen, J. and Karlsson, B. W. LU (1987) In Journal of Pediatric Gastroenterology and Nutrition 6(3). p.460-465
Abstract

High concentrations of insulin (411 ± 214 μU/ml), neurotensin-like (265 ± 72 pg/ml), and bom-besin-like immunoreactivities (1995 ± 288 pg/ml) were detected in porcine colostrum using radioimmunoassay, as compared to the levels found in sow blood serum at farrowing (5 μU/ml, <12 pg/ml, and 17 pg/ml, respectively). After 72 h of lactation, the levels of insulin and neurotensin-like immunoreactivities had decreased to 28 ± 17 μU/ml and 89 ± 23 pg/ml, respectively, while the bombesin-like activity remained constant. Characterization with reversed-phase high performance liquid chromatography showed that the insulin immunoreactivity eluted at the same position as the insulin standard, while the elution patterns of the neurotensin-like and... (More)

High concentrations of insulin (411 ± 214 μU/ml), neurotensin-like (265 ± 72 pg/ml), and bom-besin-like immunoreactivities (1995 ± 288 pg/ml) were detected in porcine colostrum using radioimmunoassay, as compared to the levels found in sow blood serum at farrowing (5 μU/ml, <12 pg/ml, and 17 pg/ml, respectively). After 72 h of lactation, the levels of insulin and neurotensin-like immunoreactivities had decreased to 28 ± 17 μU/ml and 89 ± 23 pg/ml, respectively, while the bombesin-like activity remained constant. Characterization with reversed-phase high performance liquid chromatography showed that the insulin immunoreactivity eluted at the same position as the insulin standard, while the elution patterns of the neurotensin-like and bombesin-like immunoreactivities (eluted in three separate peaks) did not correspond to that of their respective standards. The biological function of the peptide hormones in colostrum/milk may be as triggers of the developmental changes taking place in the nursing neonate, especially in the gastrointestinal tract.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bombesin, Colostrum/milk, Insulin, Neonate, Neurotensin, Pig
in
Journal of Pediatric Gastroenterology and Nutrition
volume
6
issue
3
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0023254779
  • pmid:3323439
ISSN
0277-2116
DOI
10.1002/j.1536-4801.1987.tb09324.x
language
English
LU publication?
yes
id
863656f9-3ae8-4100-95c9-a472f7b7cdf3
date added to LUP
2024-12-05 15:32:37
date last changed
2025-04-04 15:29:22
@article{863656f9-3ae8-4100-95c9-a472f7b7cdf3,
  abstract     = {{<p>High concentrations of insulin (411 ± 214 μU/ml), neurotensin-like (265 ± 72 pg/ml), and bom-besin-like immunoreactivities (1995 ± 288 pg/ml) were detected in porcine colostrum using radioimmunoassay, as compared to the levels found in sow blood serum at farrowing (5 μU/ml, &lt;12 pg/ml, and 17 pg/ml, respectively). After 72 h of lactation, the levels of insulin and neurotensin-like immunoreactivities had decreased to 28 ± 17 μU/ml and 89 ± 23 pg/ml, respectively, while the bombesin-like activity remained constant. Characterization with reversed-phase high performance liquid chromatography showed that the insulin immunoreactivity eluted at the same position as the insulin standard, while the elution patterns of the neurotensin-like and bombesin-like immunoreactivities (eluted in three separate peaks) did not correspond to that of their respective standards. The biological function of the peptide hormones in colostrum/milk may be as triggers of the developmental changes taking place in the nursing neonate, especially in the gastrointestinal tract.</p>}},
  author       = {{Weström, B. R. and Ekman, R. and Svendsen, L. and Svendsen, J. and Karlsson, B. W.}},
  issn         = {{0277-2116}},
  keywords     = {{Bombesin; Colostrum/milk; Insulin; Neonate; Neurotensin; Pig}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{460--465}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Pediatric Gastroenterology and Nutrition}},
  title        = {{Levels of immunoreactive insulin, neurotensin, and bombesin in porcine colostrum and milk}},
  url          = {{http://dx.doi.org/10.1002/j.1536-4801.1987.tb09324.x}},
  doi          = {{10.1002/j.1536-4801.1987.tb09324.x}},
  volume       = {{6}},
  year         = {{1987}},
}