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Clinical outcome and microvascular blood flow in VAC® and Sorbalgon® treated peri-vascular infected wounds in the groin after vascular surgery - an early interim analysis.

Acosta, Stefan LU ; Monsen, Christina and Dencker, Magnus LU (2013) In International Wound Journal 10(4). p.377-382
Abstract
Vacuum-assisted wound closure (VAC®) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we wanted to perform an early interim analysis of clinical outcome in these seriously ill patients at risk for amputation and death. Patients were randomised to either VAC® (n = 5) or Sorbalgon® (n = 5; best other treatment) therapy after surgical debridement. Non-invasive laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There were no difference in LDPI values in VAC® versus Sorbalgon® treated patients (P = 0·46). One patient in the VAC® group... (More)
Vacuum-assisted wound closure (VAC®) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we wanted to perform an early interim analysis of clinical outcome in these seriously ill patients at risk for amputation and death. Patients were randomised to either VAC® (n = 5) or Sorbalgon® (n = 5; best other treatment) therapy after surgical debridement. Non-invasive laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There were no difference in LDPI values in VAC® versus Sorbalgon® treated patients (P = 0·46). One patient in the VAC® group suffered from two re-bleeding episodes, leading to vascular resection and transfemoral amputation and in the Sorbalgon® group two had a complete wound healing time of more than 4 months and one had a visible interposition bypass graft in the groin after 1 month of treatment. No patient died due to the groin infection. Although not statistically proven, fewer wound treatment failures were recorded in the VAC® group, justifying this early interim analysis. LDPI studies were feasible. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Wound Journal
volume
10
issue
4
pages
377 - 382
publisher
Wiley-Blackwell
external identifiers
  • wos:000322157600006
  • pmid:22672773
  • scopus:84881552517
  • pmid:22672773
ISSN
1742-481X
DOI
10.1111/j.1742-481X.2012.00993.x
language
English
LU publication?
yes
id
863a8332-2533-4c3b-9ac7-8c33ca8bd888 (old id 2859744)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22672773?dopt=Abstract
date added to LUP
2016-04-01 10:33:03
date last changed
2019-08-23 02:16:59
@article{863a8332-2533-4c3b-9ac7-8c33ca8bd888,
  abstract     = {Vacuum-assisted wound closure (VAC®) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we wanted to perform an early interim analysis of clinical outcome in these seriously ill patients at risk for amputation and death. Patients were randomised to either VAC® (n = 5) or Sorbalgon® (n = 5; best other treatment) therapy after surgical debridement. Non-invasive laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There were no difference in LDPI values in VAC® versus Sorbalgon® treated patients (P = 0·46). One patient in the VAC® group suffered from two re-bleeding episodes, leading to vascular resection and transfemoral amputation and in the Sorbalgon® group two had a complete wound healing time of more than 4 months and one had a visible interposition bypass graft in the groin after 1 month of treatment. No patient died due to the groin infection. Although not statistically proven, fewer wound treatment failures were recorded in the VAC® group, justifying this early interim analysis. LDPI studies were feasible.},
  author       = {Acosta, Stefan and Monsen, Christina and Dencker, Magnus},
  issn         = {1742-481X},
  language     = {eng},
  number       = {4},
  pages        = {377--382},
  publisher    = {Wiley-Blackwell},
  series       = {International Wound Journal},
  title        = {Clinical outcome and microvascular blood flow in VAC® and Sorbalgon® treated peri-vascular infected wounds in the groin after vascular surgery - an early interim analysis.},
  url          = {http://dx.doi.org/10.1111/j.1742-481X.2012.00993.x},
  doi          = {10.1111/j.1742-481X.2012.00993.x},
  volume       = {10},
  year         = {2013},
}