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Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD : Relation to Disease Progression

Moreira Soares Oliveira, Bernardo LU ; Gawlik, Kinga I LU ; Durbeej, Madeleine LU and Holmberg, Johan LU (2018) In PLoS Currents 10.
Abstract

Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Currents
volume
10
publisher
Public Library of Science
ISSN
2157-3999
DOI
10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88
language
English
LU publication?
yes
id
863e547f-f0b0-43e7-bda4-edd3e7f7e682
date added to LUP
2019-09-02 06:35:36
date last changed
2019-09-04 18:16:57
@article{863e547f-f0b0-43e7-bda4-edd3e7f7e682,
  abstract     = {<p>Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD.</p>},
  author       = {Moreira Soares Oliveira, Bernardo and Gawlik, Kinga I and Durbeej, Madeleine and Holmberg, Johan},
  issn         = {2157-3999},
  language     = {eng},
  month        = {08},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD : Relation to Disease Progression},
  url          = {http://dx.doi.org/10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88},
  volume       = {10},
  year         = {2018},
}