Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD : Relation to Disease Progression
(2018) In PLoS Currents 10.- Abstract
Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/863e547f-f0b0-43e7-bda4-edd3e7f7e682
- author
- Moreira Soares Oliveira, Bernardo LU ; Gawlik, Kinga I LU ; Durbeej, Madeleine LU and Holmberg, Johan LU
- organization
- publishing date
- 2018-08-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Currents
- volume
- 10
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:30430039
- ISSN
- 2157-3999
- DOI
- 10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88
- language
- English
- LU publication?
- yes
- id
- 863e547f-f0b0-43e7-bda4-edd3e7f7e682
- date added to LUP
- 2019-09-02 06:35:36
- date last changed
- 2019-09-04 18:16:57
@article{863e547f-f0b0-43e7-bda4-edd3e7f7e682, abstract = {{<p>Circulating microRNAs (miRNAs) are being considered as non-invasive biomarkers for disease progression and clinical trials. Congenital muscular dystrophy with deficiency of laminin α2 chain (LAMA2-CMD) is a very severe form of muscular dystrophy, for which no treatment is available. In order to identify LAMA2-CMD biomarkers we have profiled miRNAs in urine from the dy2J /dy2J mouse model of LAMA2-CMD at three distinct time points (representing asymptomatic, initial and established disease). We demonstrate that unique groups of miRNAs are differentially expressed at each time point. We suggest that urine miRNAs can be sensitive biomarkers for different stages of LAMA2-CMD.</p>}}, author = {{Moreira Soares Oliveira, Bernardo and Gawlik, Kinga I and Durbeej, Madeleine and Holmberg, Johan}}, issn = {{2157-3999}}, language = {{eng}}, month = {{08}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS Currents}}, title = {{Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD : Relation to Disease Progression}}, url = {{http://dx.doi.org/10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88}}, doi = {{10.1371/currents.md.d0c203c018bc024f2f4c9791ecb05f88}}, volume = {{10}}, year = {{2018}}, }