Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins : possible cross-reaction?
(2021) In European journal of dermatology : EJD 31(6). p.741-743- Abstract
BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.
OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.
MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.
RESULTS: Positive patch test... (More)
BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.
OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.
MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.
RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.
CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.
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- author
- Sukakul, Thanisorn LU ; Svedman, Cecilia LU ; Dahlin, Jakob LU ; Bergendorff, Ola LU ; Holmström, Lena and Bruze, Magnus LU
- organization
- publishing date
- 2021-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European journal of dermatology : EJD
- volume
- 31
- issue
- 6
- pages
- 741 - 743
- publisher
- John Libbey Eurotext
- external identifiers
-
- pmid:34911671
- scopus:85124175159
- ISSN
- 1167-1122
- DOI
- 10.1684/ejd.2021.4164
- language
- English
- LU publication?
- yes
- id
- 86425f05-7f6f-479d-b7db-1622f129cf7f
- date added to LUP
- 2022-02-15 11:58:14
- date last changed
- 2024-08-08 15:50:56
@article{86425f05-7f6f-479d-b7db-1622f129cf7f, abstract = {{<p>BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.</p><p>OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.</p><p>MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.</p><p>RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.</p><p>CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.</p>}}, author = {{Sukakul, Thanisorn and Svedman, Cecilia and Dahlin, Jakob and Bergendorff, Ola and Holmström, Lena and Bruze, Magnus}}, issn = {{1167-1122}}, language = {{eng}}, month = {{12}}, number = {{6}}, pages = {{741--743}}, publisher = {{John Libbey Eurotext}}, series = {{European journal of dermatology : EJD}}, title = {{Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins : possible cross-reaction?}}, url = {{http://dx.doi.org/10.1684/ejd.2021.4164}}, doi = {{10.1684/ejd.2021.4164}}, volume = {{31}}, year = {{2021}}, }