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Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins : possible cross-reaction?

Sukakul, Thanisorn LU orcid ; Svedman, Cecilia LU ; Dahlin, Jakob LU ; Bergendorff, Ola LU ; Holmström, Lena and Bruze, Magnus LU (2021) In European journal of dermatology : EJD 31(6). p.741-743
Abstract

BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.

OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.

MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.

RESULTS: Positive patch test... (More)

BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.

OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.

MATERIALS & METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.

RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.

CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European journal of dermatology : EJD
volume
31
issue
6
pages
741 - 743
publisher
John Libbey Eurotext
external identifiers
  • pmid:34911671
  • scopus:85124175159
ISSN
1167-1122
DOI
10.1684/ejd.2021.4164
language
English
LU publication?
yes
id
86425f05-7f6f-479d-b7db-1622f129cf7f
date added to LUP
2022-02-15 11:58:14
date last changed
2024-05-30 10:05:10
@article{86425f05-7f6f-479d-b7db-1622f129cf7f,
  abstract     = {{<p>BACKGROUND: A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.</p><p>OBJECTIVES: To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.</p><p>MATERIALS &amp; METHODS: Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.</p><p>RESULTS: Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.</p><p>CONCLUSION: There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.</p>}},
  author       = {{Sukakul, Thanisorn and Svedman, Cecilia and Dahlin, Jakob and Bergendorff, Ola and Holmström, Lena and Bruze, Magnus}},
  issn         = {{1167-1122}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{6}},
  pages        = {{741--743}},
  publisher    = {{John Libbey Eurotext}},
  series       = {{European journal of dermatology : EJD}},
  title        = {{Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins : possible cross-reaction?}},
  url          = {{http://dx.doi.org/10.1684/ejd.2021.4164}},
  doi          = {{10.1684/ejd.2021.4164}},
  volume       = {{31}},
  year         = {{2021}},
}