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Ventricular-arterial coupling and cardiovascular risk among young adults : The African-PREDICT study

Holm, Hannes LU ; Kruger, Ruan ; Jujic, Amra LU ; Lamiral, Zohra ; Uys, Aletta Sophia ; Girerd, Nicolas and Magnusson, Martin LU orcid (2023) In American Journal of Physiology - Heart and Circulatory Physiology 325(2). p.362-371
Abstract

Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification, but studies on its association with anthropometric and CV factors are sparse in young individuals without overt CV disease. We aim to provide descriptive data regarding VAC and its associations with CV risk factors in young adults without overt CV disease. For 631 (mean age, 24 ± 3 yr; 51% female) individuals, VAC was determined by carotid-femoral pulse wave velocity (PWV)/global longitudinal strain (GLS). Multivariable logistic and linear regression models were performed to explore the association between PWV/GLS and CV risk factors. A
P-value < 0.05 was considered statistically significant. The mean... (More)

Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification, but studies on its association with anthropometric and CV factors are sparse in young individuals without overt CV disease. We aim to provide descriptive data regarding VAC and its associations with CV risk factors in young adults without overt CV disease. For 631 (mean age, 24 ± 3 yr; 51% female) individuals, VAC was determined by carotid-femoral pulse wave velocity (PWV)/global longitudinal strain (GLS). Multivariable logistic and linear regression models were performed to explore the association between PWV/GLS and CV risk factors. A
P-value < 0.05 was considered statistically significant. The mean PWV/GLS was 0.33 ± 0.07 m/s%. Higher ratios of PWV/GLS associated with older age, male sex, and a higher prevalence of CV risk factors (i.e., higher blood pressure, prevalent hypertension, higher waist circumference, active smoking, higher plasma triglycerides, lower high-density lipoprotein cholesterol, and an adverse urine albumin/creatinine ratio). Furthermore, higher PWV/GLS was associated with echocardiographic measures such as lower ejection fraction and higher left ventricle mass index. In expanded logistic regression models, higher ratios of PWV/GLS were significantly associated with the prevalence of active smoking [odds ratio (OR), 1.88; confidence interval (CI) 1.36-2.58,
P < 0.001] and hypertension (OR 1.98; CI 1.40-2.80,
P < 0.001). We demonstrated that worse VAC reflected by higher values of PWV/GLS are significantly associated with CV risk factors in young adults. The results suggest that PWV/GLS might serve as a tool to improve the profiling of cardiovascular risk in young adults.
NEW & NOTEWORTHY Assessing VAC is especially useful in heart failure and valvular heart disease, but less is known about VAC in the pathophysiology of CV disease risk in younger individuals. In young individuals without overt CV disease, we showed descriptive data regarding VAC, determined by PWV/GLS ratio, and explored the associations of VAC with clinical CV disease risk factors. Worse VAC, reflected by higher values of PWV/GLS, associated with high blood pressure and smoking in young adults.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Male, Female, Young Adult, Adult, Cardiovascular Diseases/diagnosis, Pulse Wave Analysis, Heart Ventricles, Risk Factors, Hypertension, Heart Disease Risk Factors, Vascular Stiffness/physiology
in
American Journal of Physiology - Heart and Circulatory Physiology
volume
325
issue
2
pages
362 - 371
publisher
American Physiological Society
external identifiers
  • scopus:85165521737
  • pmid:37389948
ISSN
1522-1539
DOI
10.1152/ajpheart.00179.2023
language
English
LU publication?
yes
id
86bd9335-e774-4ac3-8cff-809bc36db358
date added to LUP
2023-07-28 11:51:22
date last changed
2024-04-19 23:59:33
@article{86bd9335-e774-4ac3-8cff-809bc36db358,
  abstract     = {{<p>Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification, but studies on its association with anthropometric and CV factors are sparse in young individuals without overt CV disease. We aim to provide descriptive data regarding VAC and its associations with CV risk factors in young adults without overt CV disease. For 631 (mean age, 24 ± 3 yr; 51% female) individuals, VAC was determined by carotid-femoral pulse wave velocity (PWV)/global longitudinal strain (GLS). Multivariable logistic and linear regression models were performed to explore the association between PWV/GLS and CV risk factors. A<br>
 P-value &lt; 0.05 was considered statistically significant. The mean PWV/GLS was 0.33 ± 0.07 m/s%. Higher ratios of PWV/GLS associated with older age, male sex, and a higher prevalence of CV risk factors (i.e., higher blood pressure, prevalent hypertension, higher waist circumference, active smoking, higher plasma triglycerides, lower high-density lipoprotein cholesterol, and an adverse urine albumin/creatinine ratio). Furthermore, higher PWV/GLS was associated with echocardiographic measures such as lower ejection fraction and higher left ventricle mass index. In expanded logistic regression models, higher ratios of PWV/GLS were significantly associated with the prevalence of active smoking [odds ratio (OR), 1.88; confidence interval (CI) 1.36-2.58, <br>
 P &lt; 0.001] and hypertension (OR 1.98; CI 1.40-2.80, <br>
 P &lt; 0.001). We demonstrated that worse VAC reflected by higher values of PWV/GLS are significantly associated with CV risk factors in young adults. The results suggest that PWV/GLS might serve as a tool to improve the profiling of cardiovascular risk in young adults. <br>
 NEW &amp; NOTEWORTHY Assessing VAC is especially useful in heart failure and valvular heart disease, but less is known about VAC in the pathophysiology of CV disease risk in younger individuals. In young individuals without overt CV disease, we showed descriptive data regarding VAC, determined by PWV/GLS ratio, and explored the associations of VAC with clinical CV disease risk factors. Worse VAC, reflected by higher values of PWV/GLS, associated with high blood pressure and smoking in young adults.<br>
 </p>}},
  author       = {{Holm, Hannes and Kruger, Ruan and Jujic, Amra and Lamiral, Zohra and Uys, Aletta Sophia and Girerd, Nicolas and Magnusson, Martin}},
  issn         = {{1522-1539}},
  keywords     = {{Humans; Male; Female; Young Adult; Adult; Cardiovascular Diseases/diagnosis; Pulse Wave Analysis; Heart Ventricles; Risk Factors; Hypertension; Heart Disease Risk Factors; Vascular Stiffness/physiology}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{2}},
  pages        = {{362--371}},
  publisher    = {{American Physiological Society}},
  series       = {{American Journal of Physiology - Heart and Circulatory Physiology}},
  title        = {{Ventricular-arterial coupling and cardiovascular risk among young adults : The African-PREDICT study}},
  url          = {{http://dx.doi.org/10.1152/ajpheart.00179.2023}},
  doi          = {{10.1152/ajpheart.00179.2023}},
  volume       = {{325}},
  year         = {{2023}},
}