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Human bone marrow organoids : emerging progress but persisting challenges

Bourgine, Paul E. LU orcid (2025) In Trends in Biotechnology
Abstract

Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols rely on the mesodermal induction of iPSCs, establishing mesenchymal–vascular–hematopoietic tissues exhibiting fetal compositional and functional features. However, concerns on their reliability to model adult bone marrow processes exist. Given the blood ontogeny complexity, leveraging developmentally inspired programs presents a significant... (More)

Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols rely on the mesodermal induction of iPSCs, establishing mesenchymal–vascular–hematopoietic tissues exhibiting fetal compositional and functional features. However, concerns on their reliability to model adult bone marrow processes exist. Given the blood ontogeny complexity, leveraging developmentally inspired programs presents a significant challenge in establishing relevant BMO systems. While the importance of developing human BMO persists, the engineering modalities to achieve it remain cryptic.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
bone marrow, hematopoiesis, mesenchymal stem/stromal cells, organoid, pluripotent stem cells
in
Trends in Biotechnology
publisher
Elsevier
external identifiers
  • scopus:105008554875
ISSN
0167-7799
DOI
10.1016/j.tibtech.2025.05.028
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author
id
86cc2c1e-9fe8-4628-8846-46be6d07d432
date added to LUP
2025-12-19 13:16:38
date last changed
2025-12-19 13:17:16
@article{86cc2c1e-9fe8-4628-8846-46be6d07d432,
  abstract     = {{<p>Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols rely on the mesodermal induction of iPSCs, establishing mesenchymal–vascular–hematopoietic tissues exhibiting fetal compositional and functional features. However, concerns on their reliability to model adult bone marrow processes exist. Given the blood ontogeny complexity, leveraging developmentally inspired programs presents a significant challenge in establishing relevant BMO systems. While the importance of developing human BMO persists, the engineering modalities to achieve it remain cryptic.</p>}},
  author       = {{Bourgine, Paul E.}},
  issn         = {{0167-7799}},
  keywords     = {{bone marrow; hematopoiesis; mesenchymal stem/stromal cells; organoid; pluripotent stem cells}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Biotechnology}},
  title        = {{Human bone marrow organoids : emerging progress but persisting challenges}},
  url          = {{http://dx.doi.org/10.1016/j.tibtech.2025.05.028}},
  doi          = {{10.1016/j.tibtech.2025.05.028}},
  year         = {{2025}},
}