Advanced

Solvent Orange 60 is a potent contact sensitizer in occupational and everyday life

Linauskienė, Kotryna; Zimerson, Erik LU ; Antelmi, Annarita LU ; Bruze, Magnus LU ; Hagvall, Lina; Hamnerius, Nils LU ; Hauksson, Inese LU ; Ryberg, Kristina LU and Isaksson, Marléne LU (2018) In Contact Dermatitis 79(3). p.123-126
Abstract

Background: Solvent Orange (SO) 60 is a perinone-type dye that is often used in plastic materials such as spectacle frames and has been shown to cause contact allergy. The first case of SO 60 allergic contact dermatitis caused by spectacle frames was reported in 1999, and the second in 2011. We have recently seen 10 patients, of whom 6 developed dermatitis in the retroauricular/temporal area after wearing plastic spectacles. Objectives: To report the cause of the dermatitis in the 10 patients and to describe our first case with occupational SO 60 contact allergy. Methods: In this retrospective study, patch test results of 10 patients, tested with the Swedish baseline series and our specific spectacle and/or plastic series, including SO... (More)

Background: Solvent Orange (SO) 60 is a perinone-type dye that is often used in plastic materials such as spectacle frames and has been shown to cause contact allergy. The first case of SO 60 allergic contact dermatitis caused by spectacle frames was reported in 1999, and the second in 2011. We have recently seen 10 patients, of whom 6 developed dermatitis in the retroauricular/temporal area after wearing plastic spectacles. Objectives: To report the cause of the dermatitis in the 10 patients and to describe our first case with occupational SO 60 contact allergy. Methods: In this retrospective study, patch test results of 10 patients, tested with the Swedish baseline series and our specific spectacle and/or plastic series, including SO 60 1.0% pet., in 2011-2017 were analysed. Results: Ten patients, 2 males and 8 females, aged 43 to 71 years, reacted positively to SO 60 1.0% pet., namely, 4 pensioners, 2 nurses, 1 office worker, 1 teacher, 1 shop assistant, and 1 unemployed person. Four of the patients had an atopic history. Patch test reactions varied from + to +++; some had spread >20 cm outside the test area in terms of erythematous, infiltrated skin with papules. Retesting of patient no. 1 with serial dilutions of SO 60 in acetone showed positive reactions down to 1 ppm. Three patients reacted to the extracts of their earpieces. Gas chromatography-mass spectrometry was used to confirm the presence of SO 60 in 2 earpieces. Conclusions: SO 60 should be included in any spectacle patch test series that may be used. If there is a strong suspicion of contact allergy to SO 60 before patch testing, lowering the test concentration from 1.0% to 0.01% should be considered.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAS no. 6925-69-5, chemical analysis, contact allergy, hearing aid, occupational contact allergy, patch testing, spectacle frames, ultrasonic bath extract
in
Contact Dermatitis
volume
79
issue
3
pages
4 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85051816258
ISSN
0105-1873
DOI
10.1111/cod.13022
language
English
LU publication?
yes
id
86ed0f75-6fbd-4c9d-9a8d-151db83e01ce
date added to LUP
2018-09-07 11:56:47
date last changed
2019-01-06 14:03:54
@article{86ed0f75-6fbd-4c9d-9a8d-151db83e01ce,
  abstract     = {<p>Background: Solvent Orange (SO) 60 is a perinone-type dye that is often used in plastic materials such as spectacle frames and has been shown to cause contact allergy. The first case of SO 60 allergic contact dermatitis caused by spectacle frames was reported in 1999, and the second in 2011. We have recently seen 10 patients, of whom 6 developed dermatitis in the retroauricular/temporal area after wearing plastic spectacles. Objectives: To report the cause of the dermatitis in the 10 patients and to describe our first case with occupational SO 60 contact allergy. Methods: In this retrospective study, patch test results of 10 patients, tested with the Swedish baseline series and our specific spectacle and/or plastic series, including SO 60 1.0% pet., in 2011-2017 were analysed. Results: Ten patients, 2 males and 8 females, aged 43 to 71 years, reacted positively to SO 60 1.0% pet., namely, 4 pensioners, 2 nurses, 1 office worker, 1 teacher, 1 shop assistant, and 1 unemployed person. Four of the patients had an atopic history. Patch test reactions varied from + to +++; some had spread &gt;20 cm outside the test area in terms of erythematous, infiltrated skin with papules. Retesting of patient no. 1 with serial dilutions of SO 60 in acetone showed positive reactions down to 1 ppm. Three patients reacted to the extracts of their earpieces. Gas chromatography-mass spectrometry was used to confirm the presence of SO 60 in 2 earpieces. Conclusions: SO 60 should be included in any spectacle patch test series that may be used. If there is a strong suspicion of contact allergy to SO 60 before patch testing, lowering the test concentration from 1.0% to 0.01% should be considered.</p>},
  author       = {Linauskienė, Kotryna and Zimerson, Erik and Antelmi, Annarita and Bruze, Magnus and Hagvall, Lina and Hamnerius, Nils and Hauksson, Inese and Ryberg, Kristina and Isaksson, Marléne},
  issn         = {0105-1873},
  keyword      = {CAS no. 6925-69-5,chemical analysis,contact allergy,hearing aid,occupational contact allergy,patch testing,spectacle frames,ultrasonic bath extract},
  language     = {eng},
  month        = {09},
  number       = {3},
  pages        = {123--126},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Solvent Orange 60 is a potent contact sensitizer in occupational and everyday life},
  url          = {http://dx.doi.org/10.1111/cod.13022},
  volume       = {79},
  year         = {2018},
}