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Serum Zonulin and endotoxin levels in exceptional longevity versus precocious myocardial infarction

Carrera-Bastos, Pedro LU ; Picazo, óscar; Fontes-Villalba, Maelán LU ; Pareja-Galeano, Helios; Lindeberg, Staffan LU ; Martínez-Selles, Manuel; Lucia, Alejandro and Emanuele, Enzo (2018) In Aging and Disease 9(2). p.317-321
Abstract

Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum... (More)

Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum zonulin (P < 0.01) and lipopolysaccharide (P < 0.001) than young patients with acute myocardial infarction, and had significantly lower concentrations of serum lipopolysaccharide than young healthy controls (P < 0.05). No significant differences were found for soluble CD14 between groups. Our findings may stimulate further research into the role played by intestinal permeability and endotoxemia not only in coronary heart disease but also in lifespan modulation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Centenarians, Endotoxemia, Inflammation, Longevity
in
Aging and Disease
volume
9
issue
2
pages
5 pages
publisher
INT SOC AGING & DISEASE
external identifiers
  • scopus:85046086303
ISSN
2152-5250
DOI
10.14336/AD.2017.0630
language
English
LU publication?
yes
id
86efeb96-f74a-4fe6-9c3d-07f1ab6c106e
date added to LUP
2018-05-14 15:34:47
date last changed
2018-11-21 21:39:48
@article{86efeb96-f74a-4fe6-9c3d-07f1ab6c106e,
  abstract     = {<p>Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum zonulin (P &lt; 0.01) and lipopolysaccharide (P &lt; 0.001) than young patients with acute myocardial infarction, and had significantly lower concentrations of serum lipopolysaccharide than young healthy controls (P &lt; 0.05). No significant differences were found for soluble CD14 between groups. Our findings may stimulate further research into the role played by intestinal permeability and endotoxemia not only in coronary heart disease but also in lifespan modulation.</p>},
  author       = {Carrera-Bastos, Pedro and Picazo, óscar and Fontes-Villalba, Maelán and Pareja-Galeano, Helios and Lindeberg, Staffan and Martínez-Selles, Manuel and Lucia, Alejandro and Emanuele, Enzo},
  issn         = {2152-5250},
  keyword      = {Centenarians,Endotoxemia,Inflammation,Longevity},
  language     = {eng},
  month        = {04},
  number       = {2},
  pages        = {317--321},
  publisher    = {INT SOC AGING & DISEASE},
  series       = {Aging and Disease},
  title        = {Serum Zonulin and endotoxin levels in exceptional longevity versus precocious myocardial infarction},
  url          = {http://dx.doi.org/10.14336/AD.2017.0630},
  volume       = {9},
  year         = {2018},
}