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Good practice recommendations on spontaneous preterm birth

Dehaene, Isabelle ; Di Renzo, Gian Carlo ; Daskalakis, George ; Domellöf, Magnus ; Malamitsi-Puchner, Ariadne ; Modi, Neena ; Koç, Esin ; Shennan, Andrew H ; Zeitlin, Jennifer and Andersson, Ola LU orcid , et al. (2026) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 326. p.1-12
Abstract

Preterm birth continues to affect 5 to 12% of all live births in Europe and remains a leading cause of neonatal mortality and short- and long-term morbidity. Despite decades of research and clinical innovation, the overall burden has not substantially declined, and in several European settings rates are rising. This paper is a European Association of Perinatal Medicine (EAPM) Good Practice Recommendation which synthesises current evidence on spontaneous PTB (sPTB) risk and management, and examines why preterm birth persists as a clinical and public health challenge. We review the epidemiology, classification, and aetiology of sPTB; the role of the maternal microbiome; evidence-based preventive strategies; perinatal management; and... (More)

Preterm birth continues to affect 5 to 12% of all live births in Europe and remains a leading cause of neonatal mortality and short- and long-term morbidity. Despite decades of research and clinical innovation, the overall burden has not substantially declined, and in several European settings rates are rising. This paper is a European Association of Perinatal Medicine (EAPM) Good Practice Recommendation which synthesises current evidence on spontaneous PTB (sPTB) risk and management, and examines why preterm birth persists as a clinical and public health challenge. We review the epidemiology, classification, and aetiology of sPTB; the role of the maternal microbiome; evidence-based preventive strategies; perinatal management; and neonatal care. We highlight the importance of a multicomponent and evidence-based approach, focusing on primary, secondary and tertiary prevention, to reduce the human and societal cost of preterm birth across Europe.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
326
article number
115389
pages
1 - 12
publisher
Elsevier
external identifiers
  • pmid:42664766
  • scopus:105048623245
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2026.115389
language
English
LU publication?
yes
additional info
Copyright © 2026. Published by Elsevier B.V.
id
8717335a-34c5-4aed-b425-3f3e364bbb1a
date added to LUP
2026-09-09 09:39:07
date last changed
2026-09-24 04:47:45
@article{8717335a-34c5-4aed-b425-3f3e364bbb1a,
  abstract     = {{<p>Preterm birth continues to affect 5 to 12% of all live births in Europe and remains a leading cause of neonatal mortality and short- and long-term morbidity. Despite decades of research and clinical innovation, the overall burden has not substantially declined, and in several European settings rates are rising. This paper is a European Association of Perinatal Medicine (EAPM) Good Practice Recommendation which synthesises current evidence on spontaneous PTB (sPTB) risk and management, and examines why preterm birth persists as a clinical and public health challenge. We review the epidemiology, classification, and aetiology of sPTB; the role of the maternal microbiome; evidence-based preventive strategies; perinatal management; and neonatal care. We highlight the importance of a multicomponent and evidence-based approach, focusing on primary, secondary and tertiary prevention, to reduce the human and societal cost of preterm birth across Europe.</p>}},
  author       = {{Dehaene, Isabelle and Di Renzo, Gian Carlo and Daskalakis, George and Domellöf, Magnus and Malamitsi-Puchner, Ariadne and Modi, Neena and Koç, Esin and Shennan, Andrew H and Zeitlin, Jennifer and Andersson, Ola and Ehrhardt, Harald}},
  issn         = {{0301-2115}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{1--12}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}},
  title        = {{Good practice recommendations on spontaneous preterm birth}},
  url          = {{http://dx.doi.org/10.1016/j.ejogrb.2026.115389}},
  doi          = {{10.1016/j.ejogrb.2026.115389}},
  volume       = {{326}},
  year         = {{2026}},
}