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Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

Beeson, J. G.; Ndungu, F.; Persson, Kristina LU ; Chesson, J. M.; Kelly, G. L.; Uyoga, S.; Hallamore, S. L.; Williams, T. N.; Reeder, J. C. and Brown, G. V., et al. (2007) In American Journal of Tropical Medicine and Hygiene 77(1). p.22-28
Abstract
During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall... (More)
During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall than exposed multigravidas. IgG-binding was specific and did not represent antibodies to subpopulations of non-CSA-binding IEs, and some sera inhibited IE adhesion to CSA. These findings have significant implications for understanding malaria pathogenesis and immunity and may be significant for understanding the acquisition of immunity to maternal malaria. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene. (Less)
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publication status
published
subject
keywords
chondroitin-sulfate-a, variant surface-antigens, cytoadherence, characteristics, parasite adhesion, pregnant-women, var genes, distinct, adhesive, endothelial-cells, hyaluronic-acid, malaria
in
American Journal of Tropical Medicine and Hygiene
volume
77
issue
1
pages
22 - 28
publisher
AMER SOC TROP MED & HYGIENE
external identifiers
  • scopus:34548770008
ISSN
1476-1645
language
English
LU publication?
no
id
8f2925b1-a1e0-48c2-9ed8-47cdb75e58b2 (old id 8726576)
date added to LUP
2016-02-19 13:06:00
date last changed
2017-03-05 03:34:40
@article{8f2925b1-a1e0-48c2-9ed8-47cdb75e58b2,
  abstract     = {During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall than exposed multigravidas. IgG-binding was specific and did not represent antibodies to subpopulations of non-CSA-binding IEs, and some sera inhibited IE adhesion to CSA. These findings have significant implications for understanding malaria pathogenesis and immunity and may be significant for understanding the acquisition of immunity to maternal malaria. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.},
  author       = {Beeson, J. G. and Ndungu, F. and Persson, Kristina and Chesson, J. M. and Kelly, G. L. and Uyoga, S. and Hallamore, S. L. and Williams, T. N. and Reeder, J. C. and Brown, G. V. and Marsh, K.},
  issn         = {1476-1645},
  keyword      = {chondroitin-sulfate-a,variant surface-antigens,cytoadherence,characteristics,parasite adhesion,pregnant-women,var genes,distinct,adhesive,endothelial-cells,hyaluronic-acid,malaria},
  language     = {eng},
  number       = {1},
  pages        = {22--28},
  publisher    = {AMER SOC TROP MED & HYGIENE},
  series       = {American Journal of Tropical Medicine and Hygiene},
  title        = {Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa},
  volume       = {77},
  year         = {2007},
}