Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area
(2010) In PLoS ONE 5(2).- Abstract
- Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8726589
- author
- Brolin, K. J. M. ; Persson, Kristina LU ; Wahlgren, M. ; Rogerson, S. J. and Chen, Q. J.
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chondroitin sulfate-a, variant surface-antigens, sub-saharan africa, plasmodium-falciparum, infected erythrocytes, structural basis, binding, placenta, adhesion, receptor
- in
- PLoS ONE
- volume
- 5
- issue
- 2
- article number
- e9230
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:77949525251
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0009230
- language
- English
- LU publication?
- no
- additional info
- 2
- id
- 3d406fab-ed55-4e25-8f6a-c9338f4ea875 (old id 8726589)
- date added to LUP
- 2016-04-01 13:53:40
- date last changed
- 2024-01-09 20:00:34
@article{3d406fab-ed55-4e25-8f6a-c9338f4ea875, abstract = {{Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.}}, author = {{Brolin, K. J. M. and Persson, Kristina and Wahlgren, M. and Rogerson, S. J. and Chen, Q. J.}}, issn = {{1932-6203}}, keywords = {{chondroitin sulfate-a; variant surface-antigens; sub-saharan africa; plasmodium-falciparum; infected erythrocytes; structural basis; binding; placenta; adhesion; receptor}}, language = {{eng}}, number = {{2}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area}}, url = {{http://dx.doi.org/10.1371/journal.pone.0009230}}, doi = {{10.1371/journal.pone.0009230}}, volume = {{5}}, year = {{2010}}, }