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Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

Brolin, K. J. M.; Persson, Kristina LU ; Wahlgren, M.; Rogerson, S. J. and Chen, Q. J. (2010) In PLoS ONE 5(2).
Abstract
Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chondroitin sulfate-a, variant surface-antigens, sub-saharan africa, plasmodium-falciparum, infected erythrocytes, structural basis, binding, placenta, adhesion, receptor
in
PLoS ONE
volume
5
issue
2
publisher
Public Library of Science
external identifiers
  • scopus:77949525251
ISSN
1932-6203
DOI
10.1371/journal.pone.0009230
language
English
LU publication?
no
id
3d406fab-ed55-4e25-8f6a-c9338f4ea875 (old id 8726589)
date added to LUP
2016-02-19 13:04:49
date last changed
2018-05-29 10:54:57
@article{3d406fab-ed55-4e25-8f6a-c9338f4ea875,
  abstract     = {Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to alter this parity-dependent acquisition of immunity, with more severe symptoms as well as more malaria episodes in HIV positive women versus HIV negative women of a similar parity.},
  articleno    = {e9230},
  author       = {Brolin, K. J. M. and Persson, Kristina and Wahlgren, M. and Rogerson, S. J. and Chen, Q. J.},
  issn         = {1932-6203},
  keyword      = {chondroitin sulfate-a,variant surface-antigens,sub-saharan africa,plasmodium-falciparum,infected erythrocytes,structural basis,binding,placenta,adhesion,receptor},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area},
  url          = {http://dx.doi.org/10.1371/journal.pone.0009230},
  volume       = {5},
  year         = {2010},
}