Advanced

Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women : no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms

Macdonald, Helen M; McGuigan, Fiona E LU ; Lanham-New, Susan A; Fraser, William D; Ralston, Stuart H and Reid, David M (2008) In The American journal of clinical nutrition 87(5). p.20-1513
Abstract
BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.RESULTS: Compared with quartile 3 (Q3) of energy-adjusted vitamin... (More)
BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.RESULTS: Compared with quartile 3 (Q3) of energy-adjusted vitamin K(1) intake (mean: 116 microg/d), women in the lowest quartile (mean: 59 microg/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P < 0.001; LS, Q1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K(1) intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22%/y; E4: -0.71 +/- 1.17%/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.CONCLUSIONS: Vitamin K(1) intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Absorptiometry, Photon, Amino Acids, Analysis of Variance, Apolipoproteins E, Bone Density, Bone Resorption, Bone and Bones, Collagen Type I, Diet, Exercise, Factor Analysis, Statistical, Female, Humans, Middle Aged, Peptides, Polymerase Chain Reaction, Polymorphism, Genetic, Postmenopause, Scotland, Surveys and Questionnaires, Vitamin K 1, Vitamin K Deficiency
in
The American journal of clinical nutrition
volume
87
issue
5
pages
8 pages
publisher
American Society for Clinical Nutrition
external identifiers
  • scopus:43549098799
ISSN
1938-3207
language
English
LU publication?
no
id
8765b6d6-d975-4b9c-9e26-716529ab58ca
date added to LUP
2018-01-02 11:08:12
date last changed
2019-03-12 04:01:51
@article{8765b6d6-d975-4b9c-9e26-716529ab58ca,
  abstract     = {BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish women aged 49-54 y in 1990-1994 (baseline) and in 1997-2000 (visit 2). At visit 2, bone markers (urinary pyridinoline crosslinks and serum N-terminal propeptide of type 1 collagen) were measured, 3199 women completed a food-frequency questionnaire, and 2721 women were genotyped for APOE.RESULTS: Compared with quartile 3 (Q3) of energy-adjusted vitamin K(1) intake (mean: 116 microg/d), women in the lowest quartile (mean: 59 microg/d) had lower BMD (analysis of variance; FN, Q1: 0.831 +/- 0.122 g/cm(2); Q3: 0.850 +/- 0.126 g/cm(2); P &lt; 0.001; LS, Q1: 1.000 +/- 0.170 g/cm(2); Q3: 1.020 +/- 0.172 g/cm(2); P = 0.009), remaining significant at the FN after adjustment for age, weight, height, menopausal status or use of hormone replacement therapy, socioeconomic status, and physical activity (P = 0.04). Vitamin K(1) intake was associated with reduced concentrations of pyridinoline crosslinks (Q1: 5.4 +/- 2.0 nmol/mmol; Q4: 5.1 +/- 1.9 nmol/mmol; P = 0.003). Carriers of the E2 allele had greater LS BMD at visit 2 and lost less BMD than did carriers of the E4 allele (E2: -0.50 +/- 1.22%/y; E4: -0.71 +/- 1.17%/y; P = 0.05). After adjustment for confounders, the P value for BMD loss (0.03 for LS and 0.04 for FN) did not reach the level of significance required for multiple testing (P = 0.012). No interaction was observed between dietary vitamin K and APOE on BMD.CONCLUSIONS: Vitamin K(1) intake was associated with markers of bone health, but no interaction was observed with APOE alleles on BMD or markers of bone turnover.},
  author       = {Macdonald, Helen M and McGuigan, Fiona E and Lanham-New, Susan A and Fraser, William D and Ralston, Stuart H and Reid, David M},
  issn         = {1938-3207},
  keyword      = {Absorptiometry, Photon,Amino Acids,Analysis of Variance,Apolipoproteins E,Bone Density,Bone Resorption,Bone and Bones,Collagen Type I,Diet,Exercise,Factor Analysis, Statistical,Female,Humans,Middle Aged,Peptides,Polymerase Chain Reaction,Polymorphism, Genetic,Postmenopause,Scotland,Surveys and Questionnaires,Vitamin K 1,Vitamin K Deficiency},
  language     = {eng},
  number       = {5},
  pages        = {20--1513},
  publisher    = {American Society for Clinical Nutrition},
  series       = {The American journal of clinical nutrition},
  title        = {Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women : no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms},
  volume       = {87},
  year         = {2008},
}