Photocatalytic nanoparticles – From membrane interactions to antimicrobial and antiviral effects
(2022) In Advances in Colloid and Interface Science 299.- Abstract
As a result of increasing resistance among pathogens against antibiotics and anti-viral therapeutics, nanomaterials are attracting current interest as antimicrobial agents. Such materials offer triggered functionalities to combat challenging infections, based on either direct membrane action, effects of released ions, thermal shock induced by either light or magnetic fields, or oxidative photocatalysis. In the present overview, we focus on photocatalytic antimicrobial effects, in which light exposure triggers generation of reactive oxygen species. These, in turn, cause oxidative damage to key components in bacteria and viruses, including lipid membranes, lipopolysaccharides, proteins, and DNA/RNA. While an increasing body of studies... (More)
As a result of increasing resistance among pathogens against antibiotics and anti-viral therapeutics, nanomaterials are attracting current interest as antimicrobial agents. Such materials offer triggered functionalities to combat challenging infections, based on either direct membrane action, effects of released ions, thermal shock induced by either light or magnetic fields, or oxidative photocatalysis. In the present overview, we focus on photocatalytic antimicrobial effects, in which light exposure triggers generation of reactive oxygen species. These, in turn, cause oxidative damage to key components in bacteria and viruses, including lipid membranes, lipopolysaccharides, proteins, and DNA/RNA. While an increasing body of studies demonstrate that potent antimicrobial effects can be achieved by photocatalytic nanomaterials, understanding of the mechanistic foundation underlying such effects is still in its infancy. Addressing this, we here provide an overview of the current understanding of the interaction of photocatalytic nanomaterials with pathogen membranes and membrane components, and how this translates into antibacterial and antiviral effects.
(Less)
- author
- Parra-Ortiz, Elisa and Malmsten, Martin LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antibacterial, Antimicrobial, Antiviral, Membrane, Nanoparticle, Photocatalytic, Reactive oxygen species
- in
- Advances in Colloid and Interface Science
- volume
- 299
- article number
- 102526
- publisher
- Elsevier
- external identifiers
-
- scopus:85116373476
- pmid:34610862
- ISSN
- 0001-8686
- DOI
- 10.1016/j.cis.2021.102526
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Author(s)
- id
- 876bd9d1-97a1-4772-84d2-b6a6a497c1bc
- date added to LUP
- 2021-10-21 12:56:46
- date last changed
- 2024-04-20 14:46:38
@article{876bd9d1-97a1-4772-84d2-b6a6a497c1bc,
abstract = {{<p>As a result of increasing resistance among pathogens against antibiotics and anti-viral therapeutics, nanomaterials are attracting current interest as antimicrobial agents. Such materials offer triggered functionalities to combat challenging infections, based on either direct membrane action, effects of released ions, thermal shock induced by either light or magnetic fields, or oxidative photocatalysis. In the present overview, we focus on photocatalytic antimicrobial effects, in which light exposure triggers generation of reactive oxygen species. These, in turn, cause oxidative damage to key components in bacteria and viruses, including lipid membranes, lipopolysaccharides, proteins, and DNA/RNA. While an increasing body of studies demonstrate that potent antimicrobial effects can be achieved by photocatalytic nanomaterials, understanding of the mechanistic foundation underlying such effects is still in its infancy. Addressing this, we here provide an overview of the current understanding of the interaction of photocatalytic nanomaterials with pathogen membranes and membrane components, and how this translates into antibacterial and antiviral effects.</p>}},
author = {{Parra-Ortiz, Elisa and Malmsten, Martin}},
issn = {{0001-8686}},
keywords = {{Antibacterial; Antimicrobial; Antiviral; Membrane; Nanoparticle; Photocatalytic; Reactive oxygen species}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Advances in Colloid and Interface Science}},
title = {{Photocatalytic nanoparticles – From membrane interactions to antimicrobial and antiviral effects}},
url = {{http://dx.doi.org/10.1016/j.cis.2021.102526}},
doi = {{10.1016/j.cis.2021.102526}},
volume = {{299}},
year = {{2022}},
}