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Neurobiological origin of spurious brain morphological changes: A quantitative MRI study

Lorio, Sara; Kherif, Ferath; Ruef, Anne; Melie-Garcia, Lester; Frackowiak, Richard S. J.; Ashburner, John; Helms, Gunther LU ; Lutti, Antoine and Draganski, Bogdan (2016) In Human Brain Mapping 37(5). p.1801-1815
Abstract (Swedish)
Abstract in Undetermined

The high gray-white matter contrast and spatial resolution provided by T1-weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1-weighted images is predominantly driven by T1, other MRI parameters affect the image contrast, and hence brain morphological measures derived from the data. Because MRI parameters are correlates of different histological properties of brain tissue, this mixed contribution hampers the neurobiological interpretation of morphometry findings, an issue which remains largely ignored in the community. We acquired quantitative maps of the MRI parameters that determine... (More)
Abstract in Undetermined

The high gray-white matter contrast and spatial resolution provided by T1-weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1-weighted images is predominantly driven by T1, other MRI parameters affect the image contrast, and hence brain morphological measures derived from the data. Because MRI parameters are correlates of different histological properties of brain tissue, this mixed contribution hampers the neurobiological interpretation of morphometry findings, an issue which remains largely ignored in the community. We acquired quantitative maps of the MRI parameters that determine signal intensities in T1-weighted images (R1 (=1/T1), R2 *, and PD) in a large cohort of healthy subjects (n = 120, aged 18-87 years). Synthetic T1-weighted images were calculated from these quantitative maps and used to extract morphometry features-gray matter volume and cortical thickness. We observed significant variations in morphometry measures obtained from synthetic images derived from different subsets of MRI parameters. We also detected a modulation of these variations by age. Our findings highlight the impact of microstructural properties of brain tissue-myelination, iron, and water content-on automated measures of brain morphology and show that microstructural tissue changes might lead to the detection of spurious morphological changes in computational anatomy studies. They motivate a review of previous morphological results obtained from standard anatomical MRI images and highlight the value of quantitative MRI data for the inference of microscopic tissue changes in the healthy and diseased brain. Hum Brain Mapp, 2016. © 2016 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Brain Mapping
volume
37
issue
5
pages
1801 - 1815
publisher
Wiley-Blackwell
external identifiers
  • pmid:26876452
  • scopus:84959139414
  • wos:000374840600011
ISSN
1065-9471
DOI
10.1002/hbm.23137
language
English
LU publication?
yes
id
76c18320-e87c-4ca7-9e72-c4603eefaa61 (old id 8773317)
date added to LUP
2016-02-27 01:05:10
date last changed
2017-08-20 03:18:24
@article{76c18320-e87c-4ca7-9e72-c4603eefaa61,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
The high gray-white matter contrast and spatial resolution provided by T1-weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1-weighted images is predominantly driven by T1, other MRI parameters affect the image contrast, and hence brain morphological measures derived from the data. Because MRI parameters are correlates of different histological properties of brain tissue, this mixed contribution hampers the neurobiological interpretation of morphometry findings, an issue which remains largely ignored in the community. We acquired quantitative maps of the MRI parameters that determine signal intensities in T1-weighted images (R1 (=1/T1), R2 *, and PD) in a large cohort of healthy subjects (n = 120, aged 18-87 years). Synthetic T1-weighted images were calculated from these quantitative maps and used to extract morphometry features-gray matter volume and cortical thickness. We observed significant variations in morphometry measures obtained from synthetic images derived from different subsets of MRI parameters. We also detected a modulation of these variations by age. Our findings highlight the impact of microstructural properties of brain tissue-myelination, iron, and water content-on automated measures of brain morphology and show that microstructural tissue changes might lead to the detection of spurious morphological changes in computational anatomy studies. They motivate a review of previous morphological results obtained from standard anatomical MRI images and highlight the value of quantitative MRI data for the inference of microscopic tissue changes in the healthy and diseased brain. Hum Brain Mapp, 2016. © 2016 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.},
  author       = {Lorio, Sara and Kherif, Ferath and Ruef, Anne and Melie-Garcia, Lester and Frackowiak, Richard S. J. and Ashburner, John and Helms, Gunther and Lutti, Antoine and Draganski, Bogdan},
  issn         = {1065-9471},
  language     = {eng},
  month        = {02},
  number       = {5},
  pages        = {1801--1815},
  publisher    = {Wiley-Blackwell},
  series       = {Human Brain Mapping},
  title        = {Neurobiological origin of spurious brain morphological changes: A quantitative MRI study},
  url          = {http://dx.doi.org/10.1002/hbm.23137},
  volume       = {37},
  year         = {2016},
}