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Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus

Sullivan, Shannon D. ; Jablonski, Kathleen A. ; Florez, Jose C. ; Dabelea, Dana ; Franks, Paul W. LU ; Dagogo-Jack, Sam ; Kim, Catherine ; Knowler, William C. ; Christophi, Costas A. and Ratner, Robert (2014) In Diabetes Care 37(4). p.909-911
Abstract

OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS: We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS: β-Cell function was reduced in women with GDM. The GRS was... (More)

OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS: We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS: β-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS: These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to β-cell dysfunction.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
37
issue
4
pages
3 pages
publisher
American Diabetes Association
external identifiers
  • scopus:84897839935
  • pmid:24271189
ISSN
0149-5992
DOI
10.2337/dc13-0700
language
English
LU publication?
yes
id
877ad655-adcd-47b8-9505-ef33ac38bb7a
date added to LUP
2018-10-01 12:59:18
date last changed
2021-10-06 01:52:16
@article{877ad655-adcd-47b8-9505-ef33ac38bb7a,
  abstract     = {<p>OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS: We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS: β-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS: These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to β-cell dysfunction.</p>},
  author       = {Sullivan, Shannon D. and Jablonski, Kathleen A. and Florez, Jose C. and Dabelea, Dana and Franks, Paul W. and Dagogo-Jack, Sam and Kim, Catherine and Knowler, William C. and Christophi, Costas A. and Ratner, Robert},
  issn         = {0149-5992},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {909--911},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus},
  url          = {http://dx.doi.org/10.2337/dc13-0700},
  doi          = {10.2337/dc13-0700},
  volume       = {37},
  year         = {2014},
}