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The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

Twohig, Daniel LU orcid ; Rodriguez-Vieitez, Elena ; Sando, Sigrid B ; Berge, Guro ; Lauridsen, Camilla ; Møller, Ina ; Grøntvedt, Gøril R ; Bråthen, Geir ; Patra, Kalicharan and Bu, Guojun , et al. (2018) In Acta Neuropathologica Communications 6(1).
Abstract

Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and assessed links to various disease parameters in a longitudinally followed cohort (n = 136) including patients with sporadic mild cognitive impairment (MCI) and AD, and in a cross-sectional sample from the Dominantly Inherited Alzheimer's Network (n = 142) including participants carrying autosomal dominant AD (ADAD) gene mutations and their... (More)

Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and assessed links to various disease parameters in a longitudinally followed cohort (n = 136) including patients with sporadic mild cognitive impairment (MCI) and AD, and in a cross-sectional sample from the Dominantly Inherited Alzheimer's Network (n = 142) including participants carrying autosomal dominant AD (ADAD) gene mutations and their non-mutation carrying family members.Our results show that sporadic MCI patients that developed AD over a period of two years exhibited higher baseline αSyn levels (p = 0.03), which inversely correlated to their Mini-Mental State Examination scores, compared to cognitively normal controls (p = 0.02). In the same patients, there was a dose-dependent positive association between CSF αSyn and the APOEε4 allele. Further, CSF αSyn levels were higher in symptomatic ADAD mutation carriers versus non-mutation carriers (p = 0.03), and positively correlated to the estimated years from symptom onset (p = 0.05) across all mutation carriers. In asymptomatic (Clinical Dementia Rating < 0.5) PET amyloid-positive ADAD mutation carriers CSF αSyn was positively correlated to 11C-Pittsburgh Compound-B (PiB) retention in several brain regions including the posterior cingulate, superior temporal and frontal cortical areas. Importantly, APOEε4-positive ADAD mutation carriers exhibited an association between CSF αSyn levels and mean cortical PiB retention (p = 0.032). In both the sporadic AD and ADAD cohorts we found several associations predominantly between CSF levels of αSyn, tau and amyloid-β1-40.Our results suggest that higher CSF αSyn levels are linked to AD pathophysiology at the early stages of disease development and to the onset of cognitive symptoms in both sporadic and autosomal dominant AD. We conclude that APOEε4 may promote the processes driven by αSyn, which in turn may reflect on molecular mechanisms linked to the asymptomatic build-up of amyloid plaque burden in brain regions involved in the early stages of AD development.

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keywords
Aged, Alzheimer Disease/cerebrospinal fluid, Amyloid beta-Peptides/cerebrospinal fluid, Amyloid beta-Protein Precursor/cerebrospinal fluid, Aniline Compounds/pharmacokinetics, Apolipoproteins E/genetics, Brain/diagnostic imaging, Cognitive Dysfunction/cerebrospinal fluid, Cohort Studies, Cross-Sectional Studies, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Mutation/genetics, Peptide Fragments/cerebrospinal fluid, Positron-Emission Tomography, ROC Curve, Statistics, Nonparametric, Thiazoles/pharmacokinetics, alpha-Synuclein/cerebrospinal fluid, tau Proteins/cerebrospinal fluid
in
Acta Neuropathologica Communications
volume
6
issue
1
article number
130
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85057273770
  • pmid:30477568
ISSN
2051-5960
DOI
10.1186/s40478-018-0624-z
language
English
LU publication?
no
id
879b4bf7-ca38-4923-af12-acb363a29528
date added to LUP
2024-05-08 13:58:36
date last changed
2024-05-09 04:00:58
@article{879b4bf7-ca38-4923-af12-acb363a29528,
  abstract     = {{<p>Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and assessed links to various disease parameters in a longitudinally followed cohort (n = 136) including patients with sporadic mild cognitive impairment (MCI) and AD, and in a cross-sectional sample from the Dominantly Inherited Alzheimer's Network (n = 142) including participants carrying autosomal dominant AD (ADAD) gene mutations and their non-mutation carrying family members.Our results show that sporadic MCI patients that developed AD over a period of two years exhibited higher baseline αSyn levels (p = 0.03), which inversely correlated to their Mini-Mental State Examination scores, compared to cognitively normal controls (p = 0.02). In the same patients, there was a dose-dependent positive association between CSF αSyn and the APOEε4 allele. Further, CSF αSyn levels were higher in symptomatic ADAD mutation carriers versus non-mutation carriers (p = 0.03), and positively correlated to the estimated years from symptom onset (p = 0.05) across all mutation carriers. In asymptomatic (Clinical Dementia Rating &lt; 0.5) PET amyloid-positive ADAD mutation carriers CSF αSyn was positively correlated to 11C-Pittsburgh Compound-B (PiB) retention in several brain regions including the posterior cingulate, superior temporal and frontal cortical areas. Importantly, APOEε4-positive ADAD mutation carriers exhibited an association between CSF αSyn levels and mean cortical PiB retention (p = 0.032). In both the sporadic AD and ADAD cohorts we found several associations predominantly between CSF levels of αSyn, tau and amyloid-β1-40.Our results suggest that higher CSF αSyn levels are linked to AD pathophysiology at the early stages of disease development and to the onset of cognitive symptoms in both sporadic and autosomal dominant AD. We conclude that APOEε4 may promote the processes driven by αSyn, which in turn may reflect on molecular mechanisms linked to the asymptomatic build-up of amyloid plaque burden in brain regions involved in the early stages of AD development.</p>}},
  author       = {{Twohig, Daniel and Rodriguez-Vieitez, Elena and Sando, Sigrid B and Berge, Guro and Lauridsen, Camilla and Møller, Ina and Grøntvedt, Gøril R and Bråthen, Geir and Patra, Kalicharan and Bu, Guojun and Benzinger, Tammie L S and Karch, Celeste M and Fagan, Anne and Morris, John C and Bateman, Randall J and Nordberg, Agneta and White, Linda R and Nielsen, Henrietta M}},
  issn         = {{2051-5960}},
  keywords     = {{Aged; Alzheimer Disease/cerebrospinal fluid; Amyloid beta-Peptides/cerebrospinal fluid; Amyloid beta-Protein Precursor/cerebrospinal fluid; Aniline Compounds/pharmacokinetics; Apolipoproteins E/genetics; Brain/diagnostic imaging; Cognitive Dysfunction/cerebrospinal fluid; Cohort Studies; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Mutation/genetics; Peptide Fragments/cerebrospinal fluid; Positron-Emission Tomography; ROC Curve; Statistics, Nonparametric; Thiazoles/pharmacokinetics; alpha-Synuclein/cerebrospinal fluid; tau Proteins/cerebrospinal fluid}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Acta Neuropathologica Communications}},
  title        = {{The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1186/s40478-018-0624-z}},
  doi          = {{10.1186/s40478-018-0624-z}},
  volume       = {{6}},
  year         = {{2018}},
}