The possible role of the vasopressin system in hematopoiesis
(2024) In Scientific Reports 14(1).- Abstract
- Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte volume fraction (EVF)), leukocyte count (total count, lymphocytes, neutrophils) and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). The associations between increasing copeptin... (More)
- Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte volume fraction (EVF)), leukocyte count (total count, lymphocytes, neutrophils) and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). The associations between increasing copeptin tertile and the hematopoietic markers were analyzed in multivariate linear regression analyses. We found that increasing copeptin tertile was significantly (p < 0.001) associated with increasing erythrocytes, RDW, EVF, Hb, leukocytes and neutrophils after adjustment for age, sex, current smoking, prevalent diabetes, hypertension, creatinine, body mass index and physical activity. Increasing copeptin tertile was, however, not associated with change in MCV, lymphocyte or thrombocyte count. In conclusion, we found that increasing copeptin levels are positively associated with markers of erythropoiesis and leukocyte count in the general population. These results warrant further research on possible mechanistic effects of vasopressin on hematopoiesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/87a1214c-e8aa-46be-9bad-ac7dfc2440b9
- author
- Schill, Fredrika LU ; Engström, Gunnar LU ; Melander, Olle LU ; Timpka, Simon LU and Enhörning, Sofia LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiovascular Research - Hypertension (research group)
- Department of Clinical Sciences, Malmö
- Cardiovascular Research - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Perinatal and cardiovascular epidemiology (research group)
- publishing date
- 2024-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 14
- issue
- 1
- article number
- 5085
- pages
- 7 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85186444385
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-55772-5
- language
- English
- LU publication?
- yes
- id
- 87a1214c-e8aa-46be-9bad-ac7dfc2440b9
- alternative location
- https://www.nature.com/articles/s41598-024-55772-5
- date added to LUP
- 2024-03-01 12:26:24
- date last changed
- 2024-03-14 11:05:58
@article{87a1214c-e8aa-46be-9bad-ac7dfc2440b9, abstract = {{Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (erythrocyte count, hemoglobin (Hb), red blood cell distribution width (RDW), mean corpuscular volume (MCV), erythrocyte volume fraction (EVF)), leukocyte count (total count, lymphocytes, neutrophils) and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). The associations between increasing copeptin tertile and the hematopoietic markers were analyzed in multivariate linear regression analyses. We found that increasing copeptin tertile was significantly (p < 0.001) associated with increasing erythrocytes, RDW, EVF, Hb, leukocytes and neutrophils after adjustment for age, sex, current smoking, prevalent diabetes, hypertension, creatinine, body mass index and physical activity. Increasing copeptin tertile was, however, not associated with change in MCV, lymphocyte or thrombocyte count. In conclusion, we found that increasing copeptin levels are positively associated with markers of erythropoiesis and leukocyte count in the general population. These results warrant further research on possible mechanistic effects of vasopressin on hematopoiesis.}}, author = {{Schill, Fredrika and Engström, Gunnar and Melander, Olle and Timpka, Simon and Enhörning, Sofia}}, issn = {{2045-2322}}, language = {{eng}}, month = {{03}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{The possible role of the vasopressin system in hematopoiesis}}, url = {{http://dx.doi.org/10.1038/s41598-024-55772-5}}, doi = {{10.1038/s41598-024-55772-5}}, volume = {{14}}, year = {{2024}}, }