Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis : A Multinational Retrospective Study
(2023) In Journal of Rheumatology 50(9). p.1145-1151- Abstract
Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results. Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV,... (More)
Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results. Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion. We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.
(Less)
- author
- organization
- publishing date
- 2023-09-29
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ANCA-Associated vasculitis, cardiovascular events, myocardial infarction, risk factors, stroke
- in
- Journal of Rheumatology
- volume
- 50
- issue
- 9
- pages
- 7 pages
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- pmid:36642436
- scopus:85169523744
- ISSN
- 0315-162X
- DOI
- 10.3899/jrheum.220851
- language
- English
- LU publication?
- yes
- id
- 87a95ce0-6837-4d27-a190-39587a26ee6d
- date added to LUP
- 2023-10-24 11:21:17
- date last changed
- 2024-04-19 02:48:15
@article{87a95ce0-6837-4d27-a190-39587a26ee6d,
abstract = {{<p>Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results. Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion. We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.</p>}},
author = {{Moiseev, Sergey and Bulanov, Nikolay and Crnogorac, Matija and Direskeneli, Haner and Galesic, Kresimir and Gazel, Ummugulsum and Geetha, Duvuru and Guillevin, Loic and Hruškova, Zdenka and Little, Mark A. and O'Neill, Liam and Makarov, Egor and McAdoo, Stephen P. and Mohammad, Aladdin J. and Moran, Sarah and Novikov, Pavel and Pusey, Charles D. and Rahmattulla, Chinar and Satrapova, Veronika and Silva, Joana and Suvorov, Alexander and Tesar, Vladimir and Terrier, Benjamin and Willeit, Peter and Zhao, Ming Hui and Kronbichler, Andreas and Jayne, David R.W.}},
issn = {{0315-162X}},
keywords = {{ANCA-Associated vasculitis; cardiovascular events; myocardial infarction; risk factors; stroke}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{1145--1151}},
publisher = {{Journal of Rheumatology Publishing Company Limited}},
series = {{Journal of Rheumatology}},
title = {{Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis : A Multinational Retrospective Study}},
url = {{http://dx.doi.org/10.3899/jrheum.220851}},
doi = {{10.3899/jrheum.220851}},
volume = {{50}},
year = {{2023}},
}