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Bark of passiflora edulis treatment stimulates antioxidant capacity, and reduces dyslipidemia and body fat in db/db mice

Panelli, Marielle Fernanda ; Pierine, Damiana Tortolero ; de Souza, Sérgio Luiz Borges ; Ferron, Artur Júnio Togneri ; Garcia, Jéssica Leite ; Dos Santos, Klinsmann Carolo LU ; Belin, Matheus Antônio Filiol ; Lima, Giuseppina Pace Pereira ; Borguini, Milena Galhardo and Minatel, Igor Otávio , et al. (2018) In Antioxidants 7(9).
Abstract

Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n =... (More)

Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p < 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice.

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type
Contribution to journal
publication status
published
subject
keywords
Db/db mice, Obesity, Oxidative stress, Passiflora edulis
in
Antioxidants
volume
7
issue
9
article number
120
publisher
Multidisciplinary Digital Publishing Institute
external identifiers
  • scopus:85055029131
  • pmid:30205562
ISSN
2076-3921
DOI
10.3390/antiox7090120
language
English
LU publication?
no
id
87de7cb0-b3ba-4650-9d21-a09d72a156a3
date added to LUP
2019-03-28 14:26:36
date last changed
2020-01-22 07:30:59
@article{87de7cb0-b3ba-4650-9d21-a09d72a156a3,
  abstract     = {<p>Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p &lt; 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice.</p>},
  author       = {Panelli, Marielle Fernanda and Pierine, Damiana Tortolero and de Souza, Sérgio Luiz Borges and Ferron, Artur Júnio Togneri and Garcia, Jéssica Leite and Dos Santos, Klinsmann Carolo and Belin, Matheus Antônio Filiol and Lima, Giuseppina Pace Pereira and Borguini, Milena Galhardo and Minatel, Igor Otávio and Cicogna, Antônio Carlos and Francisqueti, Fabiane Valentini and Corrêa, Camila Renata},
  issn         = {2076-3921},
  language     = {eng},
  month        = {09},
  number       = {9},
  publisher    = {Multidisciplinary Digital Publishing Institute},
  series       = {Antioxidants},
  title        = {Bark of passiflora edulis treatment stimulates antioxidant capacity, and reduces dyslipidemia and body fat in db/db mice},
  url          = {http://dx.doi.org/10.3390/antiox7090120},
  doi          = {10.3390/antiox7090120},
  volume       = {7},
  year         = {2018},
}