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Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study

Olesen, Kasper; Jensen, Troels Mygind; Diaz, Lars Jorge; Møller, Anne Cathrine Laustrup; Willaing, Ingrid and Lyssenko, Valeriya LU (2017) In Journal of Clinical and Translational Endocrinology 8. p.1-5
Abstract

Aim It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA1c, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. Methods Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers. Results Mean age of the... (More)

Aim It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA1c, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. Methods Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers. Results Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA1c. Conclusions Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood-lipids, Diabetes self-management, HbA1c, LDL-C, Sense of Coherence
in
Journal of Clinical and Translational Endocrinology
volume
8
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85013909089
  • wos:000405747800001
DOI
10.1016/j.jcte.2017.01.003
language
English
LU publication?
yes
id
87ec4d90-7fda-41cc-b67b-32411625f41e
date added to LUP
2017-03-13 07:12:05
date last changed
2018-01-07 11:54:57
@article{87ec4d90-7fda-41cc-b67b-32411625f41e,
  abstract     = {<p>Aim It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA<sub>1c</sub>, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. Methods Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers. Results Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA<sub>1c</sub>. Conclusions Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors.</p>},
  author       = {Olesen, Kasper and Jensen, Troels Mygind and Diaz, Lars Jorge and Møller, Anne Cathrine Laustrup and Willaing, Ingrid and Lyssenko, Valeriya},
  keyword      = {Blood-lipids,Diabetes self-management,HbA1c,LDL-C,Sense of Coherence},
  language     = {eng},
  month        = {06},
  pages        = {1--5},
  publisher    = {Elsevier},
  series       = {Journal of Clinical and Translational Endocrinology},
  title        = {Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study},
  url          = {http://dx.doi.org/10.1016/j.jcte.2017.01.003},
  volume       = {8},
  year         = {2017},
}