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Population-based risk factors and urogenital comorbidities associated with genital herpes : A nationwide study of 4 million women

Sundqvist, Christoffer LU orcid ; Li, Xinjun LU ; Borgfeldt, Christer LU ; Forsberg, Per Ola LU ; Sundquist, Kristina LU and Jansåker, Filip LU (2024) In IJID Regions 13.
Abstract

Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemographic factors (age, educational level, family income, region of residence, and country of origin) and urogenital comorbidities (cervical carcinoma neoplasia, cystitis, vaginosis, and vulvovaginitis) and parity. National registers and primary health care data were used. Cox regression models were used to estimate hazard ratios with 95%... (More)

Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemographic factors (age, educational level, family income, region of residence, and country of origin) and urogenital comorbidities (cervical carcinoma neoplasia, cystitis, vaginosis, and vulvovaginitis) and parity. National registers and primary health care data were used. Cox regression models were used to estimate hazard ratios with 95% confidence intervals. Interactions tests were conducted. Results: A total of 15,727 women received a genital herpes diagnosis in inpatient and outpatient specialist care settings during the study period. Sociodemographic factors and parity were associated with genital herpes. than women without these comorbidities. Conclusions: Genital herpes occurs with higher rates in women of high family income, young age, Swedish origin, co-occurrence of urogenital comorbidities, and nulliparity. The findings can be used by clinicians when encountering women with these risk factors.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cervical neoplasia, Genital herpes, Herpes simplex, Sociodemographic factors, Urogenital infections
in
IJID Regions
volume
13
article number
100457
publisher
Elsevier
external identifiers
  • scopus:85205913569
  • pmid:39435377
ISSN
2772-7076
DOI
10.1016/j.ijregi.2024.100457
language
English
LU publication?
yes
id
881a84ab-8ca3-4de5-94f1-391300639234
date added to LUP
2024-11-27 11:14:11
date last changed
2024-12-11 12:54:46
@article{881a84ab-8ca3-4de5-94f1-391300639234,
  abstract     = {{<p>Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemographic factors (age, educational level, family income, region of residence, and country of origin) and urogenital comorbidities (cervical carcinoma neoplasia, cystitis, vaginosis, and vulvovaginitis) and parity. National registers and primary health care data were used. Cox regression models were used to estimate hazard ratios with 95% confidence intervals. Interactions tests were conducted. Results: A total of 15,727 women received a genital herpes diagnosis in inpatient and outpatient specialist care settings during the study period. Sociodemographic factors and parity were associated with genital herpes. than women without these comorbidities. Conclusions: Genital herpes occurs with higher rates in women of high family income, young age, Swedish origin, co-occurrence of urogenital comorbidities, and nulliparity. The findings can be used by clinicians when encountering women with these risk factors.</p>}},
  author       = {{Sundqvist, Christoffer and Li, Xinjun and Borgfeldt, Christer and Forsberg, Per Ola and Sundquist, Kristina and Jansåker, Filip}},
  issn         = {{2772-7076}},
  keywords     = {{Cervical neoplasia; Genital herpes; Herpes simplex; Sociodemographic factors; Urogenital infections}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{IJID Regions}},
  title        = {{Population-based risk factors and urogenital comorbidities associated with genital herpes : A nationwide study of 4 million women}},
  url          = {{http://dx.doi.org/10.1016/j.ijregi.2024.100457}},
  doi          = {{10.1016/j.ijregi.2024.100457}},
  volume       = {{13}},
  year         = {{2024}},
}