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Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes.

Bråred Christensson, Johanna; Karlberg, Ann-Therese; Andersen, Klaus E; Bruze, Magnus LU ; Johansen, Jeanne D; Garcia-Bravo, Begoña; Giménez Arnau, Ana; Goh, Chee-Leok; Nixon, Rosemary and White, Ian R (2016) In Contact Dermatitis
Abstract
BACKGROUND:



Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively.

OBJECTIVE:



To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients.

METHODS:



Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom.

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BACKGROUND:



Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively.

OBJECTIVE:



To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients.

METHODS:



Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom.

RESULTS:



A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene.

CONCLUSIONS:



The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:26918793
  • scopus:84960969850
  • wos:000373780300003
ISSN
0105-1873
DOI
10.1111/cod.12545
language
English
LU publication?
yes
id
13d7fc93-396c-4d6e-8c9f-c6b0ec9e7d31 (old id 8821537)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26918793?dopt=Abstract
date added to LUP
2016-03-02 15:04:26
date last changed
2017-11-13 14:33:29
@article{13d7fc93-396c-4d6e-8c9f-c6b0ec9e7d31,
  abstract     = {BACKGROUND:<br/><br>
<br/><br>
Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively.<br/><br>
OBJECTIVE:<br/><br>
<br/><br>
To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients.<br/><br>
METHODS:<br/><br>
<br/><br>
Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom.<br/><br>
RESULTS:<br/><br>
<br/><br>
A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene.<br/><br>
CONCLUSIONS:<br/><br>
<br/><br>
The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.},
  author       = {Bråred Christensson, Johanna and Karlberg, Ann-Therese and Andersen, Klaus E and Bruze, Magnus and Johansen, Jeanne D and Garcia-Bravo, Begoña and Giménez Arnau, Ana and Goh, Chee-Leok and Nixon, Rosemary and White, Ian R},
  issn         = {0105-1873},
  language     = {eng},
  month        = {02},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes.},
  url          = {http://dx.doi.org/10.1111/cod.12545},
  year         = {2016},
}