Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events.
Björkbacka, Harry LU
; Alm, Ragnar
LU
; Persson, Margaretha
LU
; Hedblad, Bo
LU
; Nilsson, Jan
LU
and Nordin Fredrikson, Gunilla
LU
(2016)
In Arteriosclerosis, Thrombosis and Vascular Biology
36.
p.765-771
- Abstract
- OBJECTIVE:
Previous smaller studies have indicated inverse associations between autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular disease. The present study investigated associations between autoantibodies against the apolipoprotein B-100 peptides p45 and p210, respectively, and risk of incident cardiovascular disease in a large population-based cohort.
APPROACH AND RESULTS:
Apolipoprotein B-100 autoantibodies were analyzed by ELISA in a prospective study, including 5393 individuals (aged 46-68 years) belonging to the cardiovascular arm of the Malmö Diet and Cancer study with a follow-up time of >15 years. Subjects that suffered an acute coronary event during... (More) - OBJECTIVE:
Previous smaller studies have indicated inverse associations between autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular disease. The present study investigated associations between autoantibodies against the apolipoprotein B-100 peptides p45 and p210, respectively, and risk of incident cardiovascular disease in a large population-based cohort.
APPROACH AND RESULTS:
Apolipoprotein B-100 autoantibodies were analyzed by ELISA in a prospective study, including 5393 individuals (aged 46-68 years) belonging to the cardiovascular arm of the Malmö Diet and Cancer study with a follow-up time of >15 years. Subjects that suffered an acute coronary event during follow-up (n=382) had lower levels at baseline of IgM autoantibodies recognizing the native and malondialdehyde-modified apolipoprotein B-100 peptides p45 and p210 and also lower IgG levels recognizing native p210, whereas no association was found with risk for stroke (n=317). Subjects in the highest compared with lowest tertile of IgM-p45MDA (hazard ratio [95% confidence interval]: 0.72 [0.55, 0.94]; P=0.017) and IgG-p210native (hazard ratio [95% confidence interval]: 0.73 [0.56, 0.97]; P=0.029) had lower risk for incident coronary events after adjustment for cardiovascular risk factors in Cox proportional hazard regression models. Moreover, subjects with high levels of IgG-p210native were less likely to have carotid plaques as assessed by ultrasonography at baseline (odds ratio=0.81, 95% confidence interval 0.70-0.95, P=0.008 after adjustment for risk factors).
CONCLUSIONS:
This large prospective study demonstrates that subjects with high levels of apolipoprotein B-100 autoantibodies have a lower risk of coronary events supporting a protective role of these autoantibodies in cardiovascular disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8821595
- author
- Björkbacka, Harry
LU
; Alm, Ragnar
LU
; Persson, Margaretha
LU
; Hedblad, Bo
LU
; Nilsson, Jan
LU
and Nordin Fredrikson, Gunilla
LU
- organization
- publishing date
- 2016-02-25
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 36
- pages
- 765 - 771
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:26916732
- scopus:84959233918
- wos:000373454700025
- pmid:26916732
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.115.306938
- language
- English
- LU publication?
- yes
- id
- f1aa7607-e38b-4781-962f-58771f6eba9c (old id 8821595)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26916732?dopt=Abstract
- date added to LUP
- 2016-04-01 10:00:00
- date last changed
- 2022-03-27 03:54:47
@article{f1aa7607-e38b-4781-962f-58771f6eba9c,
abstract = {{OBJECTIVE:<br/><br>
<br/><br>
Previous smaller studies have indicated inverse associations between autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular disease. The present study investigated associations between autoantibodies against the apolipoprotein B-100 peptides p45 and p210, respectively, and risk of incident cardiovascular disease in a large population-based cohort.<br/><br>
APPROACH AND RESULTS:<br/><br>
<br/><br>
Apolipoprotein B-100 autoantibodies were analyzed by ELISA in a prospective study, including 5393 individuals (aged 46-68 years) belonging to the cardiovascular arm of the Malmö Diet and Cancer study with a follow-up time of >15 years. Subjects that suffered an acute coronary event during follow-up (n=382) had lower levels at baseline of IgM autoantibodies recognizing the native and malondialdehyde-modified apolipoprotein B-100 peptides p45 and p210 and also lower IgG levels recognizing native p210, whereas no association was found with risk for stroke (n=317). Subjects in the highest compared with lowest tertile of IgM-p45MDA (hazard ratio [95% confidence interval]: 0.72 [0.55, 0.94]; P=0.017) and IgG-p210native (hazard ratio [95% confidence interval]: 0.73 [0.56, 0.97]; P=0.029) had lower risk for incident coronary events after adjustment for cardiovascular risk factors in Cox proportional hazard regression models. Moreover, subjects with high levels of IgG-p210native were less likely to have carotid plaques as assessed by ultrasonography at baseline (odds ratio=0.81, 95% confidence interval 0.70-0.95, P=0.008 after adjustment for risk factors).<br/><br>
CONCLUSIONS:<br/><br>
<br/><br>
This large prospective study demonstrates that subjects with high levels of apolipoprotein B-100 autoantibodies have a lower risk of coronary events supporting a protective role of these autoantibodies in cardiovascular disease.}},
author = {{Björkbacka, Harry and Alm, Ragnar and Persson, Margaretha and Hedblad, Bo and Nilsson, Jan and Nordin Fredrikson, Gunilla}},
issn = {{1524-4636}},
language = {{eng}},
month = {{02}},
pages = {{765--771}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events.}},
url = {{http://dx.doi.org/10.1161/ATVBAHA.115.306938}},
doi = {{10.1161/ATVBAHA.115.306938}},
volume = {{36}},
year = {{2016}},
}