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Novel insights in drug metabolism by MS imaging.

Sugihara, Yutaka LU ; Watanabe, Ken-ichi and Végvári, Ákos LU (2016) In Bioanalysis 8(6). p.575-588
Abstract
During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drug Metabolism and Mass Spectrometry Imaging
in
Bioanalysis
volume
8
issue
6
pages
575 - 588
publisher
Future Science
external identifiers
  • pmid:26915978
  • scopus:84960399327
  • wos:000373234900009
ISSN
1757-6180
DOI
10.4155/bio-2015-0020
language
English
LU publication?
yes
id
12d66dcf-34ab-4476-ae64-d0be2f55e775 (old id 8821635)
date added to LUP
2016-02-29 13:14:09
date last changed
2017-11-12 03:03:16
@article{12d66dcf-34ab-4476-ae64-d0be2f55e775,
  abstract     = {During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.},
  author       = {Sugihara, Yutaka and Watanabe, Ken-ichi and Végvári, Ákos},
  issn         = {1757-6180},
  keyword      = {Drug Metabolism and Mass Spectrometry Imaging},
  language     = {eng},
  number       = {6},
  pages        = {575--588},
  publisher    = {Future Science},
  series       = {Bioanalysis},
  title        = {Novel insights in drug metabolism by MS imaging.},
  url          = {http://dx.doi.org/10.4155/bio-2015-0020},
  volume       = {8},
  year         = {2016},
}