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Season of diagnosis is associated with overall survival in patients with diffuse large B-cell lymphoma but not with Hodgkin's lymphoma - A population-based Swedish Lymphoma Register study.

SZENTKIRALYI SZEKELY, ERZSÉBET LU ; Lindén, Ola LU ; Peterson, Stefan LU and Jerkeman, Mats LU (2016) In European Journal of Haematology 97(4). p.393-398
Abstract
OBJECTIVE AND METHODS:



The aim of this study was to investigate the effect of season of diagnosis on the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In this study, we included curatively treated DLBCL (n=5875) and HL (n=1693) patients, diagnosed between 2000 and 2011, based on data from the Swedish Lymphoma Register.

RESULTS:



Overall survival was significantly better for patients diagnosed with DLBCL during the summer months, but not for patients diagnosed with HL. The difference remained in a multivariable analysis adjusted for age, stage, performance status, number of extra nodal sites and year of diagnosis (HR 1.08; 95% CI 1.02-1.14, p=0.0069).... (More)
OBJECTIVE AND METHODS:



The aim of this study was to investigate the effect of season of diagnosis on the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In this study, we included curatively treated DLBCL (n=5875) and HL (n=1693) patients, diagnosed between 2000 and 2011, based on data from the Swedish Lymphoma Register.

RESULTS:



Overall survival was significantly better for patients diagnosed with DLBCL during the summer months, but not for patients diagnosed with HL. The difference remained in a multivariable analysis adjusted for age, stage, performance status, number of extra nodal sites and year of diagnosis (HR 1.08; 95% CI 1.02-1.14, p=0.0069). When analyzing the DLBCL patients according to gender in the multivariable model, the effect of season was shown to be restricted to male patients (HR=1.09, 95% CI 1.01-1.17, p=0.0269.

CONCLUSIONS:



In summary, season of diagnosis was shown to have impact on overall survival in male patients with DLBCL. Possible explanations of our results are the higher vitamin D level during the summer months, the effects of sunlight on the circadian rhythm and the immune system, or the lower risk of infectious disease during the summer. Further investigations are needed to explore these hypotheses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Haematology
volume
97
issue
4
pages
393 - 398
publisher
Wiley-Blackwell
external identifiers
  • pmid:26872557
  • scopus:84963929005
  • wos:000383698500012
ISSN
1600-0609
DOI
10.1111/ejh.12746
language
English
LU publication?
yes
id
ef69ae56-576c-4d86-90ac-7e3201aa3149 (old id 8825641)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26872557?dopt=Abstract
date added to LUP
2016-03-01 15:25:14
date last changed
2017-01-01 04:00:17
@article{ef69ae56-576c-4d86-90ac-7e3201aa3149,
  abstract     = {OBJECTIVE AND METHODS:<br/><br>
<br/><br>
The aim of this study was to investigate the effect of season of diagnosis on the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In this study, we included curatively treated DLBCL (n=5875) and HL (n=1693) patients, diagnosed between 2000 and 2011, based on data from the Swedish Lymphoma Register.<br/><br>
RESULTS:<br/><br>
<br/><br>
Overall survival was significantly better for patients diagnosed with DLBCL during the summer months, but not for patients diagnosed with HL. The difference remained in a multivariable analysis adjusted for age, stage, performance status, number of extra nodal sites and year of diagnosis (HR 1.08; 95% CI 1.02-1.14, p=0.0069). When analyzing the DLBCL patients according to gender in the multivariable model, the effect of season was shown to be restricted to male patients (HR=1.09, 95% CI 1.01-1.17, p=0.0269.<br/><br>
CONCLUSIONS:<br/><br>
<br/><br>
In summary, season of diagnosis was shown to have impact on overall survival in male patients with DLBCL. Possible explanations of our results are the higher vitamin D level during the summer months, the effects of sunlight on the circadian rhythm and the immune system, or the lower risk of infectious disease during the summer. Further investigations are needed to explore these hypotheses.},
  author       = {SZENTKIRALYI SZEKELY, ERZSÉBET and Lindén, Ola and Peterson, Stefan and Jerkeman, Mats},
  issn         = {1600-0609},
  language     = {eng},
  month        = {02},
  number       = {4},
  pages        = {393--398},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Season of diagnosis is associated with overall survival in patients with diffuse large B-cell lymphoma but not with Hodgkin's lymphoma - A population-based Swedish Lymphoma Register study.},
  url          = {http://dx.doi.org/10.1111/ejh.12746},
  volume       = {97},
  year         = {2016},
}