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Exploring the multifaceted nature of the common lymphoid progenitor compartment.

Jensen, Christina LU ; Strid, Tobias and Sigvardsson, Mikael LU (2016) In Current opinion in immunology 39. p.121-126
Abstract
While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates... (More)
While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current opinion in immunology
volume
39
pages
121 - 126
external identifiers
  • pmid:26871596
  • scopus:84957539728
  • wos:000373866000019
ISSN
1879-0372
DOI
10.1016/j.coi.2016.01.009
language
English
LU publication?
yes
id
7ddf8e05-ae74-48c7-bbed-94a1c8661dbd (old id 8825669)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26871596?dopt=Abstract
date added to LUP
2016-03-03 09:58:14
date last changed
2017-04-23 04:40:06
@article{7ddf8e05-ae74-48c7-bbed-94a1c8661dbd,
  abstract     = {While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.},
  author       = {Jensen, Christina and Strid, Tobias and Sigvardsson, Mikael},
  issn         = {1879-0372},
  language     = {eng},
  pages        = {121--126},
  series       = {Current opinion in immunology},
  title        = {Exploring the multifaceted nature of the common lymphoid progenitor compartment.},
  url          = {http://dx.doi.org/10.1016/j.coi.2016.01.009},
  volume       = {39},
  year         = {2016},
}