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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Mancina, Rosellina Margherita; Dongiovanni, Paola; Petta, Salvatore; Pingitore, Piero; Meroni, Marica; Rametta, Raffaela; Borén, Jan; Montalcini, Tiziana; Pujia, Arturo and Wiklund, Olov, et al. (2016) In Gastroenterology 150(5). p.6-1230
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.
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@article{1cb5e18f-68e6-4755-8d28-63ef5d0cffee,
  abstract     = {Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.},
  author       = {Mancina, Rosellina Margherita and Dongiovanni, Paola and Petta, Salvatore and Pingitore, Piero and Meroni, Marica and Rametta, Raffaela and Borén, Jan and Montalcini, Tiziana and Pujia, Arturo and Wiklund, Olov and Hindy, George and Spagnuolo, Rocco and Motta, Benedetta Maria and Pipitone, Rosaria Maria and Craxì, Antonio and Fargion, Silvia and Nobili, Valerio and Käkelä, Pirjo and Kärjä, Vesa and Männistö, Ville and Pihlajamäki, Jussi and Reilly, Dermot F and Castro-Perez, Jose and Kozlitina, Julia and Valenti, Luca and Romeo, Stefano},
  issn         = {1528-0012},
  language     = {eng},
  month        = {02},
  number       = {5},
  pages        = {6--1230},
  publisher    = {W B Saunders},
  series       = {Gastroenterology},
  title        = {The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.},
  url          = {http://dx.doi.org/10.1053/j.gastro.2016.01.032},
  volume       = {150},
  year         = {2016},
}