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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W and Esko, Tõnu, et al. (2016) In Nature Communications 7.
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed... (More)
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. (Less)
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Nature Communications
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7
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Nature Publishing Group
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  • pmid:26833246
  • wos:000371012200002
  • scopus:84965156172
ISSN
2041-1723
DOI
10.1038/ncomms10495
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English
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373b5228-6423-49ed-b4a6-dbff3207561d (old id 8829541)
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http://www.ncbi.nlm.nih.gov/pubmed/26833246?dopt=Abstract
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2016-03-04 10:27:23
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@article{373b5228-6423-49ed-b4a6-dbff3207561d,
  abstract     = {To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P&lt;5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.},
  articleno    = {10495},
  author       = {Lu, Yingchang and Day, Felix R and Gustafsson, Stefan and Buchkovich, Martin L and Na, Jianbo and Bataille, Veronique and Cousminer, Diana L and Dastani, Zari and Drong, Alexander W and Esko, Tõnu and Evans, David M and Falchi, Mario and Feitosa, Mary F and Ferreira, Teresa and Hedman, Åsa K and Haring, Robin and Hysi, Pirro G and Iles, Mark M and Justice, Anne E and Kanoni, Stavroula and Lagou, Vasiliki and Li, Rui and Li, Xin and Locke, Adam and Lu, Chen and Mägi, Reedik and Perry, John R B and Pers, Tune H and Qi, Qibin and Sanna, Marianna and Schmidt, Ellen M and Scott, William R and Shungin, Dmitry and Teumer, Alexander and Vinkhuyzen, Anna A E and Walker, Ryan W and Westra, Harm-Jan and Zhang, Mingfeng and Zhang, Weihua and Zhao, Jing Hua and Zhu, Zhihong and Afzal, Uzma and Ahluwalia, Tarunveer Singh and Bakker, Stephan J L and Bellis, Claire and Bonnefond, Amélie and Borodulin, Katja and Buchman, Aron S and Cederholm, Tommy and Choh, Audrey C and Choi, Hyung 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  issn         = {2041-1723},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.},
  url          = {http://dx.doi.org/10.1038/ncomms10495},
  volume       = {7},
  year         = {2016},
}