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No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families.

Nielsen, Henriette Roed; Petersen, Janne; Krogh, Lotte; Nilbert, Mef LU and Skytte, Anne-Bine (2016) In Familial Cancer 15(4). p.523-528
Abstract
In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation... (More)
In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Familial Cancer
volume
15
issue
4
pages
523 - 528
publisher
Kluwer
external identifiers
  • pmid:26951453
  • scopus:84960105817
  • wos:000382681500004
ISSN
1389-9600
DOI
10.1007/s10689-016-9898-0
language
English
LU publication?
yes
id
4af33fa8-84dd-4c32-b01a-9d78c106ffee (old id 8853114)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26951453?dopt=Abstract
date added to LUP
2016-03-15 12:17:02
date last changed
2017-03-05 04:17:54
@article{4af33fa8-84dd-4c32-b01a-9d78c106ffee,
  abstract     = {In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.},
  author       = {Nielsen, Henriette Roed and Petersen, Janne and Krogh, Lotte and Nilbert, Mef and Skytte, Anne-Bine},
  issn         = {1389-9600},
  language     = {eng},
  number       = {4},
  pages        = {523--528},
  publisher    = {Kluwer},
  series       = {Familial Cancer},
  title        = {No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families.},
  url          = {http://dx.doi.org/10.1007/s10689-016-9898-0},
  volume       = {15},
  year         = {2016},
}