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Biologically effective dose in fractionated molecular radiotherapy-application to treatment of neuroblastoma with (131)I-mIBG.

Minguez Gabina, Pablo LU ; Gustafsson, Johan Ruben LU ; Flux, Glenn and Sjögreen Gleisner, Katarina LU (2016) In Physics in Medicine and Biology 61(6). p.2532-2551
Abstract
In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration.... (More)
In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration. Modifications include both the simplistic approach of delivering this maximum permitted activity in each of the two administrations, and also the introduction of additional administrations while maintaining the protocol-prescribed total activity. For the cases studied with additional (i.e. more than two) administrations, BED of tumour and liver decreases at most 12% and 29%, respectively. The decrease in BED of the tumour is however modest compared to the two-administration schedule using the maximum permitted activity, where the decrease compared to the original schedule is 47%. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
61
issue
6
pages
2532 - 2551
publisher
IOP Publishing
external identifiers
  • pmid:26948833
  • wos:000372011300019
  • scopus:84961806555
ISSN
1361-6560
DOI
10.1088/0031-9155/61/6/2532
language
English
LU publication?
yes
id
3c6b6400-426e-4825-8cb9-e3745fe4f8f5 (old id 8856046)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26948833?dopt=Abstract
date added to LUP
2016-03-16 15:37:50
date last changed
2017-01-01 03:51:25
@article{3c6b6400-426e-4825-8cb9-e3745fe4f8f5,
  abstract     = {In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration. Modifications include both the simplistic approach of delivering this maximum permitted activity in each of the two administrations, and also the introduction of additional administrations while maintaining the protocol-prescribed total activity. For the cases studied with additional (i.e. more than two) administrations, BED of tumour and liver decreases at most 12% and 29%, respectively. The decrease in BED of the tumour is however modest compared to the two-administration schedule using the maximum permitted activity, where the decrease compared to the original schedule is 47%.},
  author       = {Minguez Gabina, Pablo and Gustafsson, Johan Ruben and Flux, Glenn and Sjögreen Gleisner, Katarina},
  issn         = {1361-6560},
  language     = {eng},
  number       = {6},
  pages        = {2532--2551},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Biologically effective dose in fractionated molecular radiotherapy-application to treatment of neuroblastoma with (131)I-mIBG.},
  url          = {http://dx.doi.org/10.1088/0031-9155/61/6/2532},
  volume       = {61},
  year         = {2016},
}