Biologically effective dose in fractionated molecular radiotherapy-application to treatment of neuroblastoma with (131)I-mIBG.
(2016) In Physics in Medicine and Biology 61(6). p.2532-2551- Abstract
- In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration.... (More)
- In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration. Modifications include both the simplistic approach of delivering this maximum permitted activity in each of the two administrations, and also the introduction of additional administrations while maintaining the protocol-prescribed total activity. For the cases studied with additional (i.e. more than two) administrations, BED of tumour and liver decreases at most 12% and 29%, respectively. The decrease in BED of the tumour is however modest compared to the two-administration schedule using the maximum permitted activity, where the decrease compared to the original schedule is 47%. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8856046
- author
- Minguez Gabina, Pablo LU ; Gustafsson, Johan Ruben LU ; Flux, Glenn and Sjögreen Gleisner, Katarina LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 61
- issue
- 6
- pages
- 2532 - 2551
- publisher
- IOP Publishing
- external identifiers
-
- pmid:26948833
- wos:000372011300019
- scopus:84961806555
- pmid:26948833
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/61/6/2532
- language
- English
- LU publication?
- yes
- id
- 3c6b6400-426e-4825-8cb9-e3745fe4f8f5 (old id 8856046)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26948833?dopt=Abstract
- date added to LUP
- 2016-04-01 10:44:16
- date last changed
- 2022-04-04 20:50:11
@article{3c6b6400-426e-4825-8cb9-e3745fe4f8f5,
abstract = {{In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration. Modifications include both the simplistic approach of delivering this maximum permitted activity in each of the two administrations, and also the introduction of additional administrations while maintaining the protocol-prescribed total activity. For the cases studied with additional (i.e. more than two) administrations, BED of tumour and liver decreases at most 12% and 29%, respectively. The decrease in BED of the tumour is however modest compared to the two-administration schedule using the maximum permitted activity, where the decrease compared to the original schedule is 47%.}},
author = {{Minguez Gabina, Pablo and Gustafsson, Johan Ruben and Flux, Glenn and Sjögreen Gleisner, Katarina}},
issn = {{1361-6560}},
language = {{eng}},
number = {{6}},
pages = {{2532--2551}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{Biologically effective dose in fractionated molecular radiotherapy-application to treatment of neuroblastoma with (131)I-mIBG.}},
url = {{https://lup.lub.lu.se/search/files/10790841/IOP_Minguez_Gabina_et_al.pdf}},
doi = {{10.1088/0031-9155/61/6/2532}},
volume = {{61}},
year = {{2016}},
}