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INVESTIGATION OF PARTIAL VOLUME EFFECT IN DIFFERENT PET/CT SYSTEMS: A COMPARISON OF RESULTS USING THE MADEIRA PHANTOM AND THE NEMA NU-2 2001 PHANTOM.

Chipiga, L; Sydoff, Marie LU ; Zvonova, I and Bernhardsson, Christian LU (2016) In Radiation Protection Dosimetry p.70-365
Abstract
Positron emission tomography combined with computed tomography (PET/CT) is a quantitative technique used for diagnosing various diseases and for monitoring treatment response for different types of tumours. However, the accuracy of the data is limited by the spatial resolution of the system. In addition, the so-called partial volume effect (PVE) causes a blurring of image structures, which in turn may cause an underestimation of activity of a structure with high-activity content. In this study, a new phantom, MADEIRA (Minimising Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations) for activity quantification in PET and single photon emission computed tomography (SPECT) was used to investigate the influence... (More)
Positron emission tomography combined with computed tomography (PET/CT) is a quantitative technique used for diagnosing various diseases and for monitoring treatment response for different types of tumours. However, the accuracy of the data is limited by the spatial resolution of the system. In addition, the so-called partial volume effect (PVE) causes a blurring of image structures, which in turn may cause an underestimation of activity of a structure with high-activity content. In this study, a new phantom, MADEIRA (Minimising Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations) for activity quantification in PET and single photon emission computed tomography (SPECT) was used to investigate the influence on the PVE by lesion size and tumour-to-background activity concentration ratio (TBR) in four different PET/CT systems. These measurements were compared with data from measurements with the NEMA NU-2 2001 phantom. The results with the MADEIRA phantom showed that the activity concentration (AC) values were closest to the true values at low ratios of TBR (<10) and reduced to 50 % of the actual AC values at high TBR (30-35). For all scanners, recovery of true values became closer to 1 with an increasing diameter of the lesion. The MADEIRA phantom showed good agreement with the results obtained from measurements with the NEMA NU-2 2001 phantom but allows for a wider range of possibilities in measuring image quality parameters. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
pages
70 - 365
publisher
Nuclear Technology Publishing
external identifiers
  • pmid:26940437
  • scopus:84978976684
  • wos:000383492100058
ISSN
1742-3406
DOI
10.1093/rpd/ncw027
language
English
LU publication?
yes
id
d744e1dd-9b41-40e3-9387-63a01d451ca2 (old id 8856318)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26940437?dopt=Abstract
date added to LUP
2016-03-16 11:02:59
date last changed
2017-01-01 06:20:26
@article{d744e1dd-9b41-40e3-9387-63a01d451ca2,
  abstract     = {Positron emission tomography combined with computed tomography (PET/CT) is a quantitative technique used for diagnosing various diseases and for monitoring treatment response for different types of tumours. However, the accuracy of the data is limited by the spatial resolution of the system. In addition, the so-called partial volume effect (PVE) causes a blurring of image structures, which in turn may cause an underestimation of activity of a structure with high-activity content. In this study, a new phantom, MADEIRA (Minimising Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations) for activity quantification in PET and single photon emission computed tomography (SPECT) was used to investigate the influence on the PVE by lesion size and tumour-to-background activity concentration ratio (TBR) in four different PET/CT systems. These measurements were compared with data from measurements with the NEMA NU-2 2001 phantom. The results with the MADEIRA phantom showed that the activity concentration (AC) values were closest to the true values at low ratios of TBR (&lt;10) and reduced to 50 % of the actual AC values at high TBR (30-35). For all scanners, recovery of true values became closer to 1 with an increasing diameter of the lesion. The MADEIRA phantom showed good agreement with the results obtained from measurements with the NEMA NU-2 2001 phantom but allows for a wider range of possibilities in measuring image quality parameters.},
  author       = {Chipiga, L and Sydoff, Marie and Zvonova, I and Bernhardsson, Christian},
  issn         = {1742-3406},
  language     = {eng},
  pages        = {70--365},
  publisher    = {Nuclear Technology Publishing},
  series       = {Radiation Protection Dosimetry},
  title        = {INVESTIGATION OF PARTIAL VOLUME EFFECT IN DIFFERENT PET/CT SYSTEMS: A COMPARISON OF RESULTS USING THE MADEIRA PHANTOM AND THE NEMA NU-2 2001 PHANTOM.},
  url          = {http://dx.doi.org/10.1093/rpd/ncw027},
  year         = {2016},
}