Advanced

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Waldhuber, Anna; Snyder, Greg A; Römmler, Franziska; Cirl, Christine; Müller, Tina; Xiao, Tsan Sam; Svanborg, Catharina LU and Miethke, Thomas (2016) In Pathogens (Basel, Switzerland) 5(25). p.1-8
Abstract
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pathogens (Basel, Switzerland)
volume
5
issue
25
pages
1 - 8
publisher
MDPI AG
external identifiers
  • pmid:26938564
  • wos:000373680700015
ISSN
2076-0817
DOI
10.3390/pathogens5010025
language
English
LU publication?
yes
id
43614675-2ea6-40da-aca2-9c4c35831e51 (old id 8856374)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26938564?dopt=Abstract
date added to LUP
2016-03-16 10:42:42
date last changed
2016-09-20 03:22:37
@article{43614675-2ea6-40da-aca2-9c4c35831e51,
  abstract     = {The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.},
  author       = {Waldhuber, Anna and Snyder, Greg A and Römmler, Franziska and Cirl, Christine and Müller, Tina and Xiao, Tsan Sam and Svanborg, Catharina and Miethke, Thomas},
  issn         = {2076-0817},
  language     = {eng},
  number       = {25},
  pages        = {1--8},
  publisher    = {MDPI AG},
  series       = {Pathogens (Basel, Switzerland)},
  title        = {A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.},
  url          = {http://dx.doi.org/10.3390/pathogens5010025},
  volume       = {5},
  year         = {2016},
}