A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.
(2016) In Pathogens 5(25). p.1-8- Abstract
- The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8856374
- author
- Waldhuber, Anna ; Snyder, Greg A ; Römmler, Franziska ; Cirl, Christine ; Müller, Tina ; Xiao, Tsan Sam ; Svanborg, Catharina LU and Miethke, Thomas
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pathogens
- volume
- 5
- issue
- 25
- pages
- 1 - 8
- publisher
- MDPI AG
- external identifiers
-
- pmid:26938564
- wos:000373680700015
- pmid:26938564
- scopus:85009196010
- ISSN
- 2076-0817
- DOI
- 10.3390/pathogens5010025
- language
- English
- LU publication?
- yes
- id
- 43614675-2ea6-40da-aca2-9c4c35831e51 (old id 8856374)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26938564?dopt=Abstract
- date added to LUP
- 2016-04-01 15:03:36
- date last changed
- 2022-04-22 06:36:44
@article{43614675-2ea6-40da-aca2-9c4c35831e51, abstract = {{The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.}}, author = {{Waldhuber, Anna and Snyder, Greg A and Römmler, Franziska and Cirl, Christine and Müller, Tina and Xiao, Tsan Sam and Svanborg, Catharina and Miethke, Thomas}}, issn = {{2076-0817}}, language = {{eng}}, number = {{25}}, pages = {{1--8}}, publisher = {{MDPI AG}}, series = {{Pathogens}}, title = {{A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.}}, url = {{https://lup.lub.lu.se/search/files/4317137/8860332.pdf}}, doi = {{10.3390/pathogens5010025}}, volume = {{5}}, year = {{2016}}, }