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Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells.

Martins, Murillo L; Ignazzi, Rosanna; Eckert, Juergen; Watts, Benjamin; Kaneno, Ramon; Zambuzzi, Willian F; Daemen, Luke; Saeki, Margarida J and Bordallo, Heloise LU (2016) In Scientific Reports 6.
Abstract
The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility... (More)
The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
6
publisher
Nature Publishing Group
external identifiers
  • pmid:26932808
  • scopus:84960155866
  • wos:000371172300001
ISSN
2045-2322
DOI
10.1038/srep22478
language
English
LU publication?
yes
id
0e3bf7d8-0a78-4149-96ff-278fe6855d07 (old id 8856543)
date added to LUP
2016-03-23 09:49:03
date last changed
2017-07-23 04:29:05
@article{0e3bf7d8-0a78-4149-96ff-278fe6855d07,
  abstract     = {The most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. From these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.},
  articleno    = {22478},
  author       = {Martins, Murillo L and Ignazzi, Rosanna and Eckert, Juergen and Watts, Benjamin and Kaneno, Ramon and Zambuzzi, Willian F and Daemen, Luke and Saeki, Margarida J and Bordallo, Heloise},
  issn         = {2045-2322},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells.},
  url          = {http://dx.doi.org/10.1038/srep22478},
  volume       = {6},
  year         = {2016},
}