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Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.

Fogelmark, Karl LU ; Peterson, Carsten LU and Troein, Carl LU (2016) In PLoS ONE 11(2).
Abstract
Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
11
issue
2
publisher
Public Library of Science
external identifiers
  • pmid:26927540
  • scopus:84960404106
  • wos:000371424200037
ISSN
1932-6203
DOI
10.1371/journal.pone.0150340
language
English
LU publication?
yes
id
804cb3de-e831-4c9f-9823-4b2829a5b896 (old id 8857051)
date added to LUP
2016-03-22 14:34:13
date last changed
2017-01-01 06:33:43
@article{804cb3de-e831-4c9f-9823-4b2829a5b896,
  abstract     = {Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.},
  articleno    = {e0150340},
  author       = {Fogelmark, Karl and Peterson, Carsten and Troein, Carl},
  issn         = {1932-6203},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0150340},
  volume       = {11},
  year         = {2016},
}