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Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity

Nasretdinov, Azat ; Barrientos, Sebastian A. LU orcid ; Brys, Ivani LU ; Halje, Pär LU and Petersson, Per LU (2023) In Frontiers in Neuroscience 17.
Abstract

Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we... (More)

Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we have here analyzed the aperiodic part of the local field potential (LFP) in rodents treated with a classic psychedelic (LSD) or a dissociative anesthetic (ketamine). In addition, functional connectivity, as quantified by mutual information measures in the LFP time series, has been assessed with in and between different structures. Our data suggest that the altered brain states of LSD and ketamine are caused by different underlying mechanisms, where LFP power shifts indicate increased neuronal activity but reduced connectivity following ketamine, while LSD also leads to reduced connectivity but without an accompanying change in LFP broadband power.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dissociative anesthetics, in vivo, LFP, neurophysiology, psychedelics
in
Frontiers in Neuroscience
volume
17
article number
1175575
publisher
Frontiers Media S. A.
external identifiers
  • pmid:37287794
  • scopus:85160999924
ISSN
1662-4548
DOI
10.3389/fnins.2023.1175575
language
English
LU publication?
yes
additional info
Funding Information: This study was supported by grants from the Kempe Foundation, Insamlingsstiftelserna, Oskarfonden, Umeå University, the Swedish Brain Foundation, Vetenskapsrådet (VR) Grants 2018-02717 and 2021-01769, Olle Engkvist Foundation, the Parkinson Foundation, Kockska Foundation, Hedlund Foundation, Åhlén Foundation, Promobilia, LU Innovation, Wenner-Gren Foundation, Royal Physiological Society in Lund, BABEL (Erasmus Mundus), Crafoord Foundation, Barncancerfonden, Magnus Bergvall Foundation, Segerfalk Foundation, Sigur & Elsa Goljes Minne Foundation, Sven-Olof Jansons Livsverk, Svenska Sällskapet för Medicinsk Forskning (SSMF), and Thurings Foundation. The computations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at LUNARC partially funded by the Swedish Research Council through grant agreement no. 2016−07213. Publisher Copyright: Copyright © 2023 Nasretdinov, Barrientos, Brys, Halje and Petersson.
id
88685404-8051-4637-8506-0fb824d20e67
date added to LUP
2023-08-01 10:59:27
date last changed
2024-04-20 00:04:58
@article{88685404-8051-4637-8506-0fb824d20e67,
  abstract     = {{<p>Psychedelic substances have in recent years attracted considerable interest as potential treatments for several psychiatric conditions, including depression, anxiety, and addiction. Imaging studies in humans point to a number of possible mechanisms underlying the acute effects of psychedelics, including changes in neuronal firing rates and excitability as well as alterations in functional connectivity between various brain nodes. In addition, animal studies using invasive recordings, have suggested synchronous high-frequency oscillations involving several brain regions as another key feature of the psychedelic brain state. To better understand how the imaging data might be related to high-resolution electrophysiological measurements, we have here analyzed the aperiodic part of the local field potential (LFP) in rodents treated with a classic psychedelic (LSD) or a dissociative anesthetic (ketamine). In addition, functional connectivity, as quantified by mutual information measures in the LFP time series, has been assessed with in and between different structures. Our data suggest that the altered brain states of LSD and ketamine are caused by different underlying mechanisms, where LFP power shifts indicate increased neuronal activity but reduced connectivity following ketamine, while LSD also leads to reduced connectivity but without an accompanying change in LFP broadband power.</p>}},
  author       = {{Nasretdinov, Azat and Barrientos, Sebastian A. and Brys, Ivani and Halje, Pär and Petersson, Per}},
  issn         = {{1662-4548}},
  keywords     = {{dissociative anesthetics; in vivo; LFP; neurophysiology; psychedelics}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neuroscience}},
  title        = {{Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity}},
  url          = {{http://dx.doi.org/10.3389/fnins.2023.1175575}},
  doi          = {{10.3389/fnins.2023.1175575}},
  volume       = {{17}},
  year         = {{2023}},
}