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Grating-based X-ray Dark-field Computed Tomography of Living Mice.

Velroyen, A ; Yaroshenko, A ; Hahn, D ; Fehringer, A ; Tapfer, A ; Müller, M ; Noël, P B ; Pauwels, B ; Sasov, A and Yildirim, A Ö , et al. (2015) In EBioMedicine 2(10). p.1500-1506
Abstract
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices... (More)
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
EBioMedicine
volume
2
issue
10
pages
1500 - 1506
publisher
Elsevier
external identifiers
  • pmid:26629545
  • wos:000365959700049
  • scopus:84951904894
  • pmid:26629545
ISSN
2352-3964
DOI
10.1016/j.ebiom.2015.08.014
language
English
LU publication?
yes
id
886f3761-99e2-4b6f-bf5d-1dd1a1a313a8 (old id 8505798)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26629545?dopt=Abstract
date added to LUP
2016-04-01 12:56:14
date last changed
2025-10-14 10:29:52
@article{886f3761-99e2-4b6f-bf5d-1dd1a1a313a8,
  abstract     = {{Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.}},
  author       = {{Velroyen, A and Yaroshenko, A and Hahn, D and Fehringer, A and Tapfer, A and Müller, M and Noël, P B and Pauwels, B and Sasov, A and Yildirim, A Ö and Eickelberg, O and Hellbach, K and Auweter, S D and Meinel, F G and Reiser, M F and Bech, Martin and Pfeiffer, F}},
  issn         = {{2352-3964}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1500--1506}},
  publisher    = {{Elsevier}},
  series       = {{EBioMedicine}},
  title        = {{Grating-based X-ray Dark-field Computed Tomography of Living Mice.}},
  url          = {{http://dx.doi.org/10.1016/j.ebiom.2015.08.014}},
  doi          = {{10.1016/j.ebiom.2015.08.014}},
  volume       = {{2}},
  year         = {{2015}},
}