Baseline prostate-specific antigen measurements and subsequent prostate cancer risk in the Danish Diet, Cancer and Health cohort
(2013) In European Journal of Cancer 49(14). p.3041-3048- Abstract
- Aim: Although prostate-specific antigen (PSA) screening reduces mortality from prostate cancer, substantial over-diagnosis and subsequent overtreatment are concerns. Early screening of men for PSA may serve to stratify the male population by risk of future clinical prostate cancer. Methods and material: Case-control study nested within the Danish 'Diet, Cancer and Health' cohort of 27,179 men aged 50-64 at enrolment. PSA measured in serum collected at cohort entry in 1993-1997 was used to evaluate prostate cancer risk diagnosed up to 14 years after. We identified 911 prostate cancer cases in the Danish Cancer Registry through 31st December 2007 1:1 age-matched with cancer-free controls. Aggressive cancer was defined as >= T3 or Gleason... (More)
- Aim: Although prostate-specific antigen (PSA) screening reduces mortality from prostate cancer, substantial over-diagnosis and subsequent overtreatment are concerns. Early screening of men for PSA may serve to stratify the male population by risk of future clinical prostate cancer. Methods and material: Case-control study nested within the Danish 'Diet, Cancer and Health' cohort of 27,179 men aged 50-64 at enrolment. PSA measured in serum collected at cohort entry in 1993-1997 was used to evaluate prostate cancer risk diagnosed up to 14 years after. We identified 911 prostate cancer cases in the Danish Cancer Registry through 31st December 2007 1:1 age-matched with cancer-free controls. Aggressive cancer was defined as >= T3 or Gleason score >= 7 or N1 or M1. Statistical analyses were based on conditional logistic regression with age as underlying time axis. Results: Total PSA and free-to-total PSA ratio at baseline were strongly associated with prostate cancer risk up to 14 years later. PSA was grouped in quintiles and free-to-total PSA ratio divided in three risk groups. The incidence rate ratio for prostate cancer was 150 (95% confidence interval, 72-310) among men with a total PSA in the highest quintile (>5.1 ng/ml) compared to the lowest (<0.80 ng/ml). The risk of aggressive cancer was highly elevated in men with a PSA level in the highest quintile. The results indicate that one-time measurement of PSA could be used in an individualised screening strategy, sparing a large proportion of men from further PSA-based screening. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4062794
- author
- Larsen, Signe Benzon ; Brasso, Klaus ; Iversen, Peter ; Christensen, Jane ; Christiansen, Michael ; Carlsson, Sigrid LU ; Lilja, Hans LU ; Friis, Soren ; Tjonneland, Anne and Dalton, Susanne Oksbjerg
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Prostate neoplasm, Prostate-specific antigen, Baseline, Risk factor, Nested case-control study
- in
- European Journal of Cancer
- volume
- 49
- issue
- 14
- pages
- 3041 - 3048
- publisher
- Elsevier
- external identifiers
-
- wos:000323604700011
- scopus:84883049851
- pmid:23684783
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2013.04.015
- language
- English
- LU publication?
- yes
- id
- 887365c4-ab79-4d82-bfc2-40d7d7435c99 (old id 4062794)
- date added to LUP
- 2016-04-01 10:43:39
- date last changed
- 2023-12-21 12:05:57
@article{887365c4-ab79-4d82-bfc2-40d7d7435c99, abstract = {{Aim: Although prostate-specific antigen (PSA) screening reduces mortality from prostate cancer, substantial over-diagnosis and subsequent overtreatment are concerns. Early screening of men for PSA may serve to stratify the male population by risk of future clinical prostate cancer. Methods and material: Case-control study nested within the Danish 'Diet, Cancer and Health' cohort of 27,179 men aged 50-64 at enrolment. PSA measured in serum collected at cohort entry in 1993-1997 was used to evaluate prostate cancer risk diagnosed up to 14 years after. We identified 911 prostate cancer cases in the Danish Cancer Registry through 31st December 2007 1:1 age-matched with cancer-free controls. Aggressive cancer was defined as >= T3 or Gleason score >= 7 or N1 or M1. Statistical analyses were based on conditional logistic regression with age as underlying time axis. Results: Total PSA and free-to-total PSA ratio at baseline were strongly associated with prostate cancer risk up to 14 years later. PSA was grouped in quintiles and free-to-total PSA ratio divided in three risk groups. The incidence rate ratio for prostate cancer was 150 (95% confidence interval, 72-310) among men with a total PSA in the highest quintile (>5.1 ng/ml) compared to the lowest (<0.80 ng/ml). The risk of aggressive cancer was highly elevated in men with a PSA level in the highest quintile. The results indicate that one-time measurement of PSA could be used in an individualised screening strategy, sparing a large proportion of men from further PSA-based screening. (C) 2013 Elsevier Ltd. All rights reserved.}}, author = {{Larsen, Signe Benzon and Brasso, Klaus and Iversen, Peter and Christensen, Jane and Christiansen, Michael and Carlsson, Sigrid and Lilja, Hans and Friis, Soren and Tjonneland, Anne and Dalton, Susanne Oksbjerg}}, issn = {{1879-0852}}, keywords = {{Prostate neoplasm; Prostate-specific antigen; Baseline; Risk factor; Nested case-control study}}, language = {{eng}}, number = {{14}}, pages = {{3041--3048}}, publisher = {{Elsevier}}, series = {{European Journal of Cancer}}, title = {{Baseline prostate-specific antigen measurements and subsequent prostate cancer risk in the Danish Diet, Cancer and Health cohort}}, url = {{http://dx.doi.org/10.1016/j.ejca.2013.04.015}}, doi = {{10.1016/j.ejca.2013.04.015}}, volume = {{49}}, year = {{2013}}, }