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Phosphorylation of human AQP2 and its role in trafficking

Törnroth-Horsefield, Susanna LU (2020) In Vitamins and Hormones 112. p.95-117
Abstract

Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to and from the apical membrane is controlled by multiple phosphorylation sites in the AQP2 C-terminus, the phosphorylation of which alters its affinity to proteins within the cellular membrane protein trafficking machinery. The aim of this chapter is to provide a summary of what is currently known about AVP-mediated AQP2 trafficking, dissecting... (More)

Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to and from the apical membrane is controlled by multiple phosphorylation sites in the AQP2 C-terminus, the phosphorylation of which alters its affinity to proteins within the cellular membrane protein trafficking machinery. The aim of this chapter is to provide a summary of what is currently known about AVP-mediated AQP2 trafficking, dissecting the roles of individual phosphorylation sites, kinases and phosphatases and interacting proteins. From this, the picture of an immensely complex process emerges, of which many structural and molecular details remains to be elucidated.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Membrane protein, Phosphorylation, Trafficking, Urine volume regulation, Water channel
host publication
Vitamins and Hormones
series title
Vitamins and Hormones
editor
Litwack, Gerald
volume
112
pages
23 pages
publisher
Academic Press
external identifiers
  • scopus:85072066228
  • pmid:32061351
ISSN
0083-6729
ISBN
9780128208090
DOI
10.1016/bs.vh.2019.08.002
language
English
LU publication?
yes
id
8896b6ed-7590-47d3-bb6d-843b0b5553ca
date added to LUP
2021-01-15 10:39:49
date last changed
2024-07-25 09:50:22
@inbook{8896b6ed-7590-47d3-bb6d-843b0b5553ca,
  abstract     = {{<p>Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to and from the apical membrane is controlled by multiple phosphorylation sites in the AQP2 C-terminus, the phosphorylation of which alters its affinity to proteins within the cellular membrane protein trafficking machinery. The aim of this chapter is to provide a summary of what is currently known about AVP-mediated AQP2 trafficking, dissecting the roles of individual phosphorylation sites, kinases and phosphatases and interacting proteins. From this, the picture of an immensely complex process emerges, of which many structural and molecular details remains to be elucidated.</p>}},
  author       = {{Törnroth-Horsefield, Susanna}},
  booktitle    = {{Vitamins and Hormones}},
  editor       = {{Litwack, Gerald}},
  isbn         = {{9780128208090}},
  issn         = {{0083-6729}},
  keywords     = {{Membrane protein; Phosphorylation; Trafficking; Urine volume regulation; Water channel}},
  language     = {{eng}},
  pages        = {{95--117}},
  publisher    = {{Academic Press}},
  series       = {{Vitamins and Hormones}},
  title        = {{Phosphorylation of human AQP2 and its role in trafficking}},
  url          = {{http://dx.doi.org/10.1016/bs.vh.2019.08.002}},
  doi          = {{10.1016/bs.vh.2019.08.002}},
  volume       = {{112}},
  year         = {{2020}},
}